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OPIOID INDUCED ALTERATIONS OF IMMUNE STATUS

阿片类药物引起的免疫状态改变

基本信息

批准号：
6378268
负责人：
DONALD T LYSLE
金额：
$ 9.33万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-05-01 至 2002-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6378268
关键词：
albino rat autoradiography buprenorphine conditioning dosage drug abuse endogenous opioid immune system immunopharmacology methadone methadylacetate morphine naltrexone neuroimmunomodulation nitric oxide opioid receptor psychoneuroimmunology

项目摘要

These goals will be accomplished within the framework of three existing NIH funded projects. The first project, entitled Behavioral Determinants of Opioid/Immune Interactions, provides an examination of Opioid-induced alterations of immune status with emphasis on the role of the central nervous system and pharmacological variables in these interactions. Specifically, the proposal is to conduct studies on the effects of acute and chronic Opioid administration on immune function, and identify the specific brain regions involved in those effects. The second project entitled Immune Alterations Mediated by conditioning, examines how conditioning processes can modulate immune status. This proposal involves examining the role of endogenous opiates in conditioned modulation of immune function. The third project, entitled Opioid-induced alterations of nitric oxide production by peripheral macrophages. This project will determine the subtype(s) of Opioid receptors involved in Opioid-induced alterations of nitric oxide production, and characterize the effect of Opioid administration on nitric oxide production in vivo. Collectively, these projects will provide important new information about Opioid- induced modulation of the immune system, and this award will enhance these investigations.

这些目标将在三个框架内实现现有 NIH 资助的项目。第一个项目名为“行为” 阿片类药物/免疫相互作用的决定因素，提供了检查阿片类药物引起的免疫状态改变，重点是中枢神经系统和药理学变量的作用这些相互作用。具体来说，建议开展研究急性和慢性阿片类药物给药对免疫的影响功能，并确定参与这些功能的特定大脑区域影响。第二个项目名为“免疫改变介导” 调节，检查调节过程如何调节免疫状态。该提案涉及审查内源性阿片类药物对免疫功能的条件调节。第三个项目，题为阿片类药物引起的一氧化氮改变由外周巨噬细胞产生。该项目将决定参与阿片类药物诱导的阿片类受体亚型一氧化氮产生的变化，并表征其影响阿片类药物给药对体内一氧化氮产生的影响。总的来说，这些项目将提供有关阿片类药物的重要新信息诱导免疫系统调节，该奖项将加强这些调查。