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ACTIVIN STRUCTURE-FUNCTION RELATIONSHIPS

ACTIVIN STRUCTURE-FUNCTION RELATIONSHIPS
激活素结构-功能关系
批准号：
6301871
负责人：
WOLFGANG H FISCHER
金额：
$19.74万
依托单位：
SALK INSTITUTE FOR BIOLOGICAL STUDIES
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-04-01 至 2001-03-31
来源：
https://reporter.nih.gov/project-details/6301871
关键词：
X ray crystallography biological signal transduction cell line chimeric proteins follistatin growth factor receptors hormone binding protein hormone receptor inhibin mutant peptide hormone analog point mutation protein protein interaction protein purification protein structure function receptor binding recombinant proteins site directed mutagenesis transforming growth factors

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英文摘要
Activin is a pluripotent hormone/growth factor that is involved in important biological functions including reproduction, development, and cell differentiation and survival. This Project studies the molecular events that lead to signal propagation by this protein. Activin interacts with two classes of cell surface mutant activin molecules to study the events that initiate signal transduction. We will employ X-ray crystallographic and mutagenesis data obtained by this Program to design these mutants. The initial interaction with activin type II receptors will be analyzed in detail. The mechanism of interaction with type I regulation of these events will be investigated. To further our understanding of the specific activities of the related proteins activin and TGFbeta, we will generate chimeric molecules and test these in biological systems specific for each of these factors.
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An FT Mass Spectrometer to Identify Posttranslational Modifications
CORE--TECHNICAL CORE
STRUCTURE FUNCTION RELATIONSHIPS OF ACTIVIN AND ITS RECEPTORS
CORE--TECHNICAL CORE
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