DEVELOPMENT OF SCREENING METHOD FOR SIMIAN FOAMY VIRUS

猿泡沫病毒筛选方法的建立

• 批准号: 6312897
• 负责人: SCOTT W WONG
• 金额: $ 12.86万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6312897
• 关键词: Chordata; epidemiology; nutrition; nutrition related tag

Premenopausal black women have a 2- to 3-fold greater rate of coronary heart disease (CHD) than premenopausal white women. The purpose of this study was to provide greater insight into the reasons for this difference, which are currently unclear. We compared CHD risk factors in 99 black and 100 white, healthy, premenopausal women, aged 18 to 45 years, and of relatively advantaged socioeconomic status. Compared with white women, black women had a higher body mass index (32.0 _ 9.2 vs 29.0 _ 9.4 kg/m2, p=0.021), and higher systolic (124 _17 vs 115 _ 14 mm Hg, p<0.0001) and diastolic (79 _ 14 vs 75 _ 11 mm Hg, p=0.048) blood pressures. The mean plasma lipoprotein(a) concentration was markedly higher in the black women (40.2 _ 31.3 mg/dl) than in the white women (19.2 _ 23.7 mg/dl, p<0.0001). The plasma total homocysteine level was also higher in the black women (8.80 _ 3.38 vs 7.81 _ 2.58 umol/L, p=0.013). The black women, however, had lower plasma triglyceride levels (0.91 _ 0.46 vs 1.22 _ 0.60 mmol/L, p<0.0001), and a trend toward higher high-density lipoprotein (HDL) cholesterol levels (1.37 _ 0.34 vs 1.29 _ 0.31 mmol/L, p=0.064) than the white women. Plasma total and low-density lipoprotein (LDL) cholesterol levels were similar, despite a greater consumption of saturated fat and cholesterol by the black women. Rates of cigarette smoking and alcohol intake were low and similar between the races. Premenopausal black women had a higher mean body mass index, blood pressure, lipoprotein(a), and plasma total homocysteine level, and a greater consumption of saturated fat and cholesterol than white women. These differences in coronary risk factors may place the black women in our study at increased risk for CHD compared with the white women. FUNDING Collaboration with Dr. Gerhard at OHSU PUBLICATIONS Gerhard GT, Sexton G, Malinow MR, Wander RC, Connor SL, Pappu AS, Connor WE. Premenopausal black women have more risk factors for coronary heart disease than white women. Am J Cardiol 82:1040-1045, 1998.

绝经前黑人女性的绝经率是男性的2- 3倍。 冠心病（CHD）高于绝经前白色女性。 的 这项研究的目的是提供更深入的了解原因， 这种差异，目前还不清楚。 我们比较了CHD 99名黑人和100名白色健康绝经前妇女的危险因素， 年龄在18至45岁之间， status. 与白色女性相比，黑人女性的体重更高 指数（32.0 _ 9.2 vs 29.0 _ 9.4 kg/m2，p=0.021）和较高的收缩压 (124_17 vs 115 _ 14 mm Hg，p<0.0001）和舒张压（79 _ 14 vs 75 _ 11 mm Hg，p=0.048）血压。 平均血浆脂蛋白（a） 黑人女性的浓度明显较高（40.2 _ 31.3 白色妇女（19.2 - 23.7 mg/dl，P<0.0001）。 的 血浆总同型半胱氨酸水平在黑人妇女中也较高 (8.80_ 3.38 vs7.81_ 2.58 umol/L，p=0.013）。 黑人女性， 但血浆甘油三酯水平较低（0.91 - 0.46 vs 1.22 _ 0.60 mmol/L，p<0.0001），并有高密度的趋势 脂蛋白（HDL）胆固醇水平（1.37 _ 0.34 vs 1.29 _ 0.31 mmol/L，p=0.064）高于白色女性。 血浆总密度和低密度 脂蛋白（LDL）胆固醇水平相似，尽管更高， 饱和脂肪和胆固醇的摄入量。 吸烟率和饮酒率低， 在种族之间。 绝经前黑人女性的平均身材 质量指数、血压、脂蛋白（a）和血浆总 高半胱氨酸水平，以及更多的饱和脂肪和 比白色女性的胆固醇水平高。 冠状动脉风险的这些差异 这些因素可能会使我们研究中的黑人女性患上 冠心病与白色妇女比较。 资助与博士合作。 Gerhard GT，Sexton G，Malinow MR，Wander RC，康纳SL，Pappu AS，康纳WE. 绝经前的黑人女性 冠心病的危险因素比白色女性多。 Am J Cardiol 82：1040-1045，1998.