Cancer Prevention Training: Epidemiology, Nutrition, Genetics & Survivorship

项目摘要/摘要--癌症预防领域的跨学科性质 需要广泛的研究技能。在过去的14年里，我们进行了R25培训计划 它提供了多学科的培训，重点是人体营养、运动、 遗传学和相关代谢途径在癌症易感性和预防中的作用我们已经有了大量的 成功完成实习生学位，招聘少数族裔，并安置博士后和博士后研究员 研究密集型职位。在这次更新中，我们建议继续我们的T32计划培训，包括 重视营养、其他生活方式因素、遗传和代谢途径与癌症的关系 预防，特别强调生存。该计划的目标是为学员提供 有三个领域的正式课程：流行病学、营养学和遗传学/人类生物学；实习生 在一个领域接受初级指导的人将在这些领域中的另一个领域完成二级培训；2) 在癌症预防和生存研究方面的创新和跨学科研究经验， 强调人类营养、遗传和相关代谢途径；以及3)在赠款中的技能和实践 写作、准备科学手稿、口头陈述和制定长期职业规划，以 促进为独立研究事业做准备。 我们建议每年培训4名博士后和3名博士后实习生。正式的课程和学位将 以华盛顿大学三个参与项目为基础：流行病学、营养学、 和公共卫生遗传学。每位学员将完成本培训计划开发的新课程， 包括他/她的博士领域之外的第二领域。课程设置一直在持续进行 修订以反映癌症生物学中的新兴领域，快速变化的基因和 生物标记物分析及其在更广泛的公共卫生背景下的整合。学员将在以下方面获得经验 弗雷德·哈钦森癌症研究中心三个项目内的癌症预防研究：癌症 预防、流行病学和转化研究。学员将有机会接触到大量的研究 这三个项目的资源，以及22位杰出的教师导师，他们都有 培训方案领域的外部资助研究。新的导师被增加为初级导师 教职员工展示了研究的成功，并在新的领域增加了专业知识(癌症存活率， 经济学)。学员将有来自至少两个学科的导师。项目总监将由以下人员提供建议 由参与方案的领导人以及一名外部顾问组成的指导委员会 委员会审议阶段。完成这一计划的学员将拥有以下知识和研究能力 独立进行前沿和有影响力的翻译调查；我们预计他们将成为 全国癌症预防研究的领先者。

PROJECT SUMMARY/ABSTRACT – The interdisciplinary nature of the field of cancer prevention requires a broad spectrum of research skills. In the past 14 years, we have conducted a R25 Training Program which provided multidisciplinary training with emphasis on the relationships of human nutrition, exercise, genetics and related metabolic pathways in cancer susceptibility and prevention. We have had substantial success in trainee degree completion, minority recruitment, and placement of pre- and post-doctoral fellows in research-intensive positions. In this renewal, we are proposing to continue our training as a T32 program with emphasis on the relationships of nutrition, other lifestyle factors, genetics and metabolic pathways in cancer prevention, with an additional emphasis on survivorship. The objectives of this program are to provide trainees with 1) formal coursework in three fields: Epidemiology, Nutrition, and Genetics/Human Biology; trainees whose primary instruction is in one area will complete secondary training in another of these areas; 2) innovative and transdisciplinary research experiences in cancer prevention and survivorship research, with emphasis on human nutrition, genetics and associated metabolic pathways; and 3) skills and practice in grant writing, preparing scientific manuscripts, giving oral presentations and developing a long-term career plan, to promote preparation towards an independent research career. We propose to train 4 pre- and 3 post-doctoral trainees each year. Formal coursework and degrees will be based in three participating programs of the University of Washington: Epidemiology, Nutritional Sciences, and Public Health Genetics. Each trainee will complete a new curriculum developed by this Training Program, including that in a secondary area outside the field of his/her PhD. The curriculum has been continuously revised to reflect emerging areas in cancer biology, the rapidly changing technologies for genetic and biomarker assays and their integration in the broader public health context. Trainees will gain experience in cancer prevention research within three programs of the Fred Hutchinson Cancer Research Center: Cancer Prevention, Epidemiology, and Translational Research. Trainees will have access to the considerable research resources of these three programs, as well as to the 22 exceptional faculty mentors, all of whom have externally funded research in the areas of the Training Program. New mentors have been added as junior faculty members demonstrated research success and to add expertise in new areas (cancer survivorship, omics). Trainees will have mentors from at least two disciplines. The Program Director will be advised by a Steering Committee composed of leaders of the participating programs, as well as by an External Advisory Committee. Trainees who complete this program will have the knowledge and research capabilities to independently conduct cutting edge and impactful translational investigations; we expect that they will become the nation's leaders in cancer prevention research.