Cancer Prevention Training: Epidemiology, Nutrition, Genetics & Survivorship

项目概要/摘要-癌症预防领域的跨学科性质 需要广泛的研究技能在过去的14年里，我们开展了R25培训计划， 提供多学科培训，重点是人类营养、锻炼 癌症易感性和预防中的遗传学和相关代谢途径。我们有大量的 成功完成实习生学位，少数民族的招聘，并安置博士前和博士后研究员， 研究密集型职位。在这次更新中，我们建议继续我们的培训作为一个T32计划， 强调营养、其他生活方式因素、遗传学和代谢途径与癌症的关系 预防为主，更注重生存。该计划的目标是为学员提供 1）三个领域的正式课程：流行病学，营养学和遗传学/人类生物学;学员 其主要教学是在一个领域，将完成另一个这些领域的中学培训; 2） 在癌症预防和生存研究方面的创新和跨学科研究经验， 强调人类营养，遗传学和相关的代谢途径;和3）在补助金的技能和实践 写作，准备科学手稿，做口头报告和制定长期职业计划， 为独立的研究生涯做好准备。 我们建议每年培养4名博士生和3名博士后。正式的课程和学位将 基于华盛顿大学的三个参与项目：流行病学、营养科学、 公共卫生遗传学每个受训者将完成本培训计划开发的新课程， 包括在他/她的博士领域之外的第二领域。该课程一直在 修订以反映癌症生物学的新兴领域，快速变化的遗传和 生物标志物测定及其在更广泛的公共卫生背景下的整合。学员将获得以下方面的经验： 弗雷德哈钦森癌症研究中心的三个项目中的癌症预防研究： 预防，流行病学和转化研究。学员将有机会接触到大量的研究， 这三个项目的资源，以及22个特殊的教师导师，他们都有 外部资助的研究在培训计划的领域。新的导师已被添加为初级 教职员工展示了研究的成功，并增加了新领域的专业知识（癌症生存， 组学）。学员将有来自至少两个学科的导师。项目主任将由一名 指导委员会由参与计划的领导人以及外部顾问组成 以马克思完成该计划的学员将拥有知识和研究能力， 独立进行前沿和有影响力的翻译研究;我们希望他们将成为 国家癌症预防研究的领导者

PROJECT SUMMARY/ABSTRACT – The interdisciplinary nature of the field of cancer prevention requires a broad spectrum of research skills. In the past 14 years, we have conducted a R25 Training Program which provided multidisciplinary training with emphasis on the relationships of human nutrition, exercise, genetics and related metabolic pathways in cancer susceptibility and prevention. We have had substantial success in trainee degree completion, minority recruitment, and placement of pre- and post-doctoral fellows in research-intensive positions. In this renewal, we are proposing to continue our training as a T32 program with emphasis on the relationships of nutrition, other lifestyle factors, genetics and metabolic pathways in cancer prevention, with an additional emphasis on survivorship. The objectives of this program are to provide trainees with 1) formal coursework in three fields: Epidemiology, Nutrition, and Genetics/Human Biology; trainees whose primary instruction is in one area will complete secondary training in another of these areas; 2) innovative and transdisciplinary research experiences in cancer prevention and survivorship research, with emphasis on human nutrition, genetics and associated metabolic pathways; and 3) skills and practice in grant writing, preparing scientific manuscripts, giving oral presentations and developing a long-term career plan, to promote preparation towards an independent research career. We propose to train 4 pre- and 3 post-doctoral trainees each year. Formal coursework and degrees will be based in three participating programs of the University of Washington: Epidemiology, Nutritional Sciences, and Public Health Genetics. Each trainee will complete a new curriculum developed by this Training Program, including that in a secondary area outside the field of his/her PhD. The curriculum has been continuously revised to reflect emerging areas in cancer biology, the rapidly changing technologies for genetic and biomarker assays and their integration in the broader public health context. Trainees will gain experience in cancer prevention research within three programs of the Fred Hutchinson Cancer Research Center: Cancer Prevention, Epidemiology, and Translational Research. Trainees will have access to the considerable research resources of these three programs, as well as to the 22 exceptional faculty mentors, all of whom have externally funded research in the areas of the Training Program. New mentors have been added as junior faculty members demonstrated research success and to add expertise in new areas (cancer survivorship, omics). Trainees will have mentors from at least two disciplines. The Program Director will be advised by a Steering Committee composed of leaders of the participating programs, as well as by an External Advisory Committee. Trainees who complete this program will have the knowledge and research capabilities to independently conduct cutting edge and impactful translational investigations; we expect that they will become the nation's leaders in cancer prevention research.