RESTORATION OF MUSCLE FUNCTION DURING REHABILITATION

本研究的目的是探讨空间 乳酸酸中毒患儿脑内乳酸分布的研究 1H光谱成像。 脑乳酸酸中毒可能发生在一些 非常不同的条件。 先天性代谢缺陷影响 乳酸-丙酮酸代谢或导致次级乳酸代谢的代谢 酸积累是其中的一部分。 使用1D，4阶， 横向阿达玛光谱成像（HSI）和二维化学 偏移成像（CSI）或2D CSI。 通过混合技术， 可以获得覆盖大脑更大体积的切片。 的 感兴趣的体积通常是7 x7 x4 cm 3。 我们将这项技术应用于临床。 的 患者人群由诊断为 先天性缺陷，例如乳酸代谢，线粒体 脑病，病因不明的原发性乳酸酸中毒。 数据 在几项患者研究中获得的结果显示， 脑乳酸积累。 空间分布格局 乳酸盐可以鉴定线粒体的不同亚群， 分别受到不同代谢疾病的影响。

The purpose of this study is to investigate the spatial distribution of brain lactate in children with lactic acidosis using 1H spectroscopic imaging. Brain lactic acidosis may occur in a number of very different conditions. Inborn errors of metabolism affecting the lactate-pyruvate metabolism or those leading to secondary lactic acid accumulation represent some of them. Data are acquired using either a hybrid of 1D, 4th order, transverse Hadamard Spectroscopic Imaging (HSI) and a 2D Chemical Shift Imaging (CSI) or a 2D CSI. With the hybrid technique multiple slices can be obtained, covering a greater volume of the brain. The volume of interest usually is 7x7x4 cm3. We apply this technique into the clinical setting. The patient population consists of children with the diagnosis of an inborn error of for instance the lactate metabolism, mitochondrial encephalopathies, primary lactic acidosis of unknown etiology. Data obtained in several patient studies revealed regional differences of brain lactate accumulation. The pattern of spatial distribution of lactate may identify different subsets of mitochondria which can be affected separately by different metabolic diseases.