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DETERMINATION OF 3D STRUCTURE OF RNA OLIGONUCLEOTIDE BY NMR SPECTROSCOPY

DETERMINATION OF 3D STRUCTURE OF RNA OLIGONUCLEOTIDE BY NMR SPECTROSCOPY
通过核磁共振波谱法测定 RNA 寡核苷酸的 3D 结构
批准号:
6309022
负责人:
IGNACIO TINOCO
金额:
$2.74万
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-02-01 至 2002-01-14

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中文摘要
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英文摘要
The SIR provided [U_13C, 15 N]RNA on dry ice; 2g This research project will examine RNA ofigonucleotides by 2 and 3 dimensional heteronuclear NMR studies. Labeled ribonucleotides will make it possible to determine the solution-state conformation of RNA molecules which cannot be done otherwise. The Resource cultured methylotrophic bacterial on 13C-labeled methanol. These bacterial were provided to the investigators. They isolated ribonucleotides from the bacteria and re-synthesized RNA oligonucleotides. NMR studies are being carried out.
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DETERMINATION OF 3D STRUCTURE OF RNA OLIGONUCLEOTIDE BY NMR SPECTROSCOPY
DETERMINATION OF 3D STRUCTURE OF RNA OLIGONUCLEOTIDE BY NMR SPECTROSCOPY
THE SAN FRANCISCO LASER CENTER
THE SAN FRANCISCO LASER CENTER
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