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STRUCTURE AND FUNCTION OF NUCLEIC ACIDS

STRUCTURE AND FUNCTION OF NUCLEIC ACIDS
核酸的结构和功能
批准号：
3268152
负责人：
IGNACIO TINOCO
金额：
$29.43万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
1976
资助国家：
美国
项目状态：
已结题
起止时间：
1976-12-01 至 1989-11-30
来源：
https://reporter.nih.gov/project-details/3268152
关键词：
chemical structure function chromatography circular dichroism conformation nuclear magnetic resonance spectroscopy nucleic acid chemical synthesis nucleic acid sequence nucleic acid structure oligonucleotides temperature jump thermodynamics

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中文摘要
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英文摘要
The goal of this project is to obtain a fundamental understanding of the conformations of nucleic acids and of the forces which govern them. We will seek useful correlations between the base sequence of a nucleic acid and its structure and biological function. A better understanding of nucleic acids may help in the prevention or cure of all diseases which depend on the functions of nucleic acids. These include viral diseases, genetic diseases and cancer. Oligonucleotides of specific base sequence will be synthesized to provide structural elements of DNA, RNA and DNA-RNA hybrids. Thermodynamics and kinetics of formation of complementary double-strand helices, mismatched helices and hairpin loops will be measured. Conformations will be determined in solution using one-and two- dimensional nuclear magnetic resonance measurements. Tertiary and higher-order folded structures in nucleic acids will be studied using absorption and scattering of circularly polarized light.
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