CELL CYCLE PROGRESSION IN NIJMEGEN BREAKPOINT SYNDROME IRRADIATED CELLS

奈梅亨断点综合征照射细胞的细胞周期进展

• 批准号: 6327957
• 负责人: M KRAAKMAN-VAN DER ZWET
• 金额: $ 0.31万
• 依托单位: UNIVERSITY OF CALIF-LOS ALAMOS NAT LAB
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6327957
• 关键词: biomedical resource; human tissue; nucleic acids; proteins

Nijmegen breakage syndrome (NBS) is characterized by extreme sensitivity of ionizing radiation and increased risk for cancer. Multiparameter flow cytometry, including BrdU content analysis, is being used to investigate the DNA damage responses, including cell cycle arrest, in primary NBS fibroblast cell line. Initial studies indicate that NBS cells show normal G1 and G2 arrest in response to ionizing radiation. In on going studies we will further examine the effect of radiation on other NBS cell lines with potentially different breakage syndromes.

奈亨断裂综合征（NBS）的特点是极端