OXIDANTS AND NITRIC OXIDE IN CORONARY VASCULAR FUNCTION

冠状血管功能中的氧化剂和一氧化氮

基本信息

  • 批准号:
    6316700
  • 负责人:
  • 金额:
    $ 39.44万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-07-01 至 2001-08-31
  • 项目状态:
    已结题

项目摘要

The long-range goals of this project are to develop an understanding of the roles and mechanisms of action of oxidant and nitric oxide interactions in vascular function in the coronary circulation and to identify alterations that occur in these processes in the heart failure and exercise training models examined in the Program Project. The first objective is to determine mechanisms that control the production and metabolism of superoxide anion (O(2)) and its interaction with endothelium-derived nitric oxide (NO) that are of potential relevance to signalling functions of (1) the normal coronary circulation and (2) alterations in tissues derived from collaborations within the Program Project on heart failure and exercise training. The second objective is to determine how signalling mechanisms involved in the control coronary vascular tone in normal arteries are altered by O(2))-NO interactions and how changes in this interaction in vascular tissue derived from during heart failure and exercise trained animals result in alterations in mechanisms that control force generation. The third objective is to elucidate the mechanism(s) involved in the control of cardiac (and skeletal muscle) tissue respiration by endothelium-derived NO, with a focus on the role of oxidant interactions in normal cardiac muscle and to identify changes in the function of these processes in tissues derived from the heart failure and exercise training models. Studies in this project examining new signalling mechanisms will be conducted in isolated calf coronary arteries, microvessels and cardiac muscle slices. The collaborative studies focused on examining changes in signalling mechanisms will be conducted on: isolated normal and failing dog coronary arteries, microvessels and cardiac and skeletal muscle slices and isolated normal and exercised rat aorta and skeletal muscle slices, and isolated normal and failing human heart muscle. Collaborative studies on changes in the activity, enzyme levels and mRNA of NO synthase and SOD enzymes will also be employed to identify the origins of changes in the failure and exercise training models. The results of these studies should provide valuable information for understanding the role of oxidant and NO interactions in the function of the coronary circulation, and in identifying changes that occur in the role and mechanism of action of these vascular function-related processes in heart failure and exercise training.
这个项目的长期目标是发展对……的理解

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Michael S Wolin其他文献

Influence of heme metabolism and redox regulation of sGC in the control of vascular function
  • DOI:
    10.1186/1471-2210-7-s1-s33
  • 发表时间:
    2007-07-25
  • 期刊:
  • 影响因子:
    2.700
  • 作者:
    Michael S Wolin;Sachin A Gupte;Mansoor Ahmad;Christopher J Mingone
  • 通讯作者:
    Christopher J Mingone

Michael S Wolin的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Michael S Wolin', 18)}}的其他基金

ecSOD derived peroxide in pulmonary adaptation to hypoxia
ecSOD 衍生的过氧化物在肺适应缺氧中的作用
  • 批准号:
    8582142
  • 财政年份:
    2013
  • 资助金额:
    $ 39.44万
  • 项目类别:
ecSOD derived peroxide in pulmonary adaptation to hypoxia
ecSOD 衍生的过氧化物在肺适应缺氧中的作用
  • 批准号:
    9102162
  • 财政年份:
    2013
  • 资助金额:
    $ 39.44万
  • 项目类别:
ecSOD derived peroxide in pulmonary adaptation to hypoxia
ecSOD 衍生的过氧化物在肺适应缺氧中的作用
  • 批准号:
    8722598
  • 财政年份:
    2013
  • 资助金额:
    $ 39.44万
  • 项目类别:
Oxidants and Nitric Oxide in Coronary Vascular Function
氧化剂和一氧化氮对冠状血管功能的影响
  • 批准号:
    7252866
  • 财政年份:
    2007
  • 资助金额:
    $ 39.44万
  • 项目类别:
OXIDANTS AND NITRIC OXIDE IN CORONARY VASCULAR FUNCTION
冠状血管功能中的氧化剂和一氧化氮
  • 批准号:
    6931013
  • 财政年份:
    2004
  • 资助金额:
    $ 39.44万
  • 项目类别:
REACTIVE OXYGEN SPECIES AND VASCULAR O2 SENSING
活性氧和血管 O2 传感
  • 批准号:
    6391212
  • 财政年份:
    2000
  • 资助金额:
    $ 39.44万
  • 项目类别:
Reactive Oxygen Species and Vascular O2 Sensing
活性氧和血管 O2 传感
  • 批准号:
    7330318
  • 财政年份:
    2000
  • 资助金额:
    $ 39.44万
  • 项目类别:
Reactive Oxygen Species and Vascular O2 Sensing
活性氧和血管 O2 传感
  • 批准号:
    7540423
  • 财政年份:
    2000
  • 资助金额:
    $ 39.44万
  • 项目类别:
REACTIVE OXYGEN SPECIES AND VASCULAR O2 SENSING
活性氧和血管 O2 传感
  • 批准号:
    6619564
  • 财政年份:
    2000
  • 资助金额:
    $ 39.44万
  • 项目类别:
Reactive Oxygen Species and Vascular O2 Sensing
活性氧和血管 O2 传感
  • 批准号:
    7162982
  • 财政年份:
    2000
  • 资助金额:
    $ 39.44万
  • 项目类别:

相似海外基金

Cellular respiration and energy analyzer of living cells in high troughput
高通量活细胞呼吸和能量分析仪
  • 批准号:
    467735073
  • 财政年份:
    2021
  • 资助金额:
    $ 39.44万
  • 项目类别:
    Major Research Instrumentation
Mechanisms of cellular respiration-dependent cell lysis and its impact on biofilm formation and disassembly in Staphylococcus aureus.
细胞呼吸依赖性细胞裂解机制及其对金黄色葡萄球菌生物膜形成和分解的影响。
  • 批准号:
    10412146
  • 财政年份:
    2018
  • 资助金额:
    $ 39.44万
  • 项目类别:
Mechanisms of cellular respiration-dependent cell lysis and its impact on biofilm formation and disassembly in Staphylococcus aureus.
细胞呼吸依赖性细胞裂解机制及其对金黄色葡萄球菌生物膜形成和分解的影响。
  • 批准号:
    10165478
  • 财政年份:
    2018
  • 资助金额:
    $ 39.44万
  • 项目类别:
Physical regulation of cellular respiration by membrane lipid composition
膜脂成分对细胞呼吸的物理调节
  • 批准号:
    1715681
  • 财政年份:
    2017
  • 资助金额:
    $ 39.44万
  • 项目类别:
    Standard Grant
Single cell-encapsulation in hydrogels triggered by cellular respiration
由细胞呼吸触发的水凝胶中的单细胞封装
  • 批准号:
    16K14490
  • 财政年份:
    2016
  • 资助金额:
    $ 39.44万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Transcriptional regulatory mechanisms of the genes controlling cellular respiration or mitochondrial function in thermogenic skunk cabbage
产热臭甘蓝中控制细胞呼吸或线粒体功能的基因的转录调控机制
  • 批准号:
    24880027
  • 财政年份:
    2012
  • 资助金额:
    $ 39.44万
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
Cellular and sub-cellular respiration system
细胞和亚细胞呼吸系统
  • 批准号:
    315868-2005
  • 财政年份:
    2004
  • 资助金额:
    $ 39.44万
  • 项目类别:
    Research Tools and Instruments - Category 1 (<$150,000)
Cellular Respiration Bioenergetics
细胞呼吸生物能学
  • 批准号:
    6660105
  • 财政年份:
    2002
  • 资助金额:
    $ 39.44万
  • 项目类别:
Mechanism of Redox-linked Proton Pumping in Terminal Enzyme of Cellular Respiration Studied by Pulse Radiolysis
脉冲放射分解研究细胞呼吸终末酶氧化还原连接质子泵浦机制
  • 批准号:
    14380318
  • 财政年份:
    2002
  • 资助金额:
    $ 39.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Cellular Respiration Bioenergetics
细胞呼吸生物能学
  • 批准号:
    6585988
  • 财政年份:
    2002
  • 资助金额:
    $ 39.44万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了