EXTENSIONS OF MICROMACHINED MICROELECTRODE TECHNOLOGY

微加工微电极技术的延伸

• 批准号: 6324810
• 负责人: KENSALL D WISE
• 金额: $ 23.83万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6324810
• 关键词: bioengineering /biomedical engineering; biomedical resource; ear; medical rehabilitation related tag; nervous system; prosthesis; technology /technique

This project is designed to extend the basic passive probe technology to make the probes more versatile by giving them more ways to interact with the cells which surround them. We have developed and successfully implemented a process which allows the inclusion of chemical delivery channels on the same substrate as the conductive electrode sites. This permits multipoint drug delivery and multichannel recording and/or stimulation with minimal tissue disruption. Successful packaging techniques for the chemical delivery probes have been developed which permit handling and use in the normal context of acute pharmacological characterization of neuronal activity. In vitro tests have verified the passage of quantified doses of fluid to a surrounding medium. In vivo tests of simultaneous chemical delivery and extracellular recordings in guinea pig inferior and superior colliculus are demonstrating results consistent with conventional approaches. Data presented at meetings including that of the 1998 Association for Research in Otolaryngology has generated much interest in the device by the neuroscience community. New devices have been fabricated which have configurations relevant to specific neurophysiological studies to be carried out in Dr. Bledsoe's laboratory. Developments during the past year include the development of an in-line flowmeter for monitoring of the dose chemical delivered.

本项目旨在扩展基本无源探头