Novel Crosslink Polymers for Dental Restorations

用于牙齿修复的新型交联聚合物

• 批准号: 6333044
• 负责人: Christopher N Bowman
• 金额: $ 26.63万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-15 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6333044
• 关键词: biomaterial development /preparation; chemical bond; chemical kinetics; chemical models; chemical structure; chemical synthesis; composite resins; copolymer I; crosslink; density; dental materials; diol; ethylene glycols; hardness; mechanical stress; model design /development; monomer; oral facial restoration material; polymerization; polymers; polymethacrylate; temperature; tensile strength

DESCRIPTION: Each year hundreds of millions of Dental restorations is performed, and an ever-increasing fraction of these restorations involve the use of photopolymerizable polymer composites. Unfortunately, these composites still suffer from problems associated with polymerization shrinkage, the long timeframe for polymerization, lack of toughness of the resin material, thermal expansion mismatch, moisture uptake by the sample following polymerization, the presence of extractable, unreacted monomer following cure, inhibition of the polymerization by oxygen, and a general lack of understanding of the polymerization process. The result of these problems is often the premature failure of composite restorations. In this research critical shortcomings are addressed by 1) developing novel monomer systems that will be more rapidly polymerizable, reach higher double bond conversions, improve the mechanical properties, and limit the effects of oxygen inhibition, 2) evaluating which aspects of the cure methodology are important in dictating how much polymerization shrinkage stress develops, and 3) developing a model that accurately predicts the polymerization kinetics as a function of temperature, initiation conditions (e.g., concentrations, light intensity, wavelengths), and composition. In addition to all of the property benefits, the success of this research in developing a more rapidly curing composite will improve the economics for the Dentist and, more importantly, will lead to improved compliance in the curing of thick restorations. It would be much simpler to fill a cavity in layers if each layer polymerizes significantly more rapidly than the current formulations. These results will combine to yield dramatically improved Dental composite systems.

描述：每年数亿个牙科修复体是 执行，这些修复的不断增长涉及 使用光聚合聚合物复合材料。不幸的是，这些复合材料 仍然遭受与聚合收缩相关的问题，长期 聚合的时间范围，树脂材料缺乏韧性，热量 聚合后，样品的膨胀不匹配，样品吸收水分， 治愈后存在可提取的，未反应的单体，抑制 氧气聚合，一般缺乏对 聚合过程。这些问题的结果通常是为时过早 复合修复体的失败。在这项研究中，关键的缺点是 由1）开发新型单体系统，这些系统将更快地 可聚合，达到更高的双键转换，改善机械 性质，并限制氧抑制的影响，2）评估哪个 治疗方法的各个方面对于决定多少 聚合收缩应力发展，3）开发一个模型，该模型 准确地预测聚合动力学是温度的函数， 起始条件（例如，浓度，光强度，波长）和 作品。除了所有财产福利之外， 开发更快速固化综合的研究将改善 牙医的经济学，更重要的是，将导致改善 固化厚实修复的依从性。要简单得多 如果每一层聚合更快地填充层次 比目前的配方。这些结果将结合起来急剧产生 改进的牙科复合系统。