Developing a technique to measure levels of tumour hypoxia during proton beam therapy through gamma-ray spectroscopy

开发一种通过伽马射线光谱测量质子束治疗期间肿瘤缺氧水平的技术

• 批准号: ST/P003141/1
• 负责人: Michael Taylor
• 金额: $ 5.8万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FP003141%2F1
• 关键词: Developing; technique; measure; levels; tumour

Around 50% of patients receive radiotherapy as part of their cancer treatment. One of the most important factors influencing clinical outcome, following radiotherapy, is tumour hypoxia. Low oxygen levels (hypoxia), is a characteristic of the tumour microenvironment which drives increased metastatic potential and confers resistance to radiotherapy, decreasing overall survival. However, even with advances in radiotherapy, including a move towards proton beam therapy (PBT), hypoxia-mediated radio-resistance is a complexity that remains. This project aims to develop a technique to measure oxygen levels, and consequently hypoxia, in tumours treated with PBT in real time. During PBT, dose is deposited in tissue by both the ionisation of atomic electrons and proton interactions with the atomic nuclei. This project takes a multidisciplinary approach to harness the naturally produced radiation during PBT to measure hypoxia. Real time measurement of hypoxia during treatment will inform adaptive therapy where radiation dose can be escalated to overcome hypoxic radio-resistance during fractionated treatment planning.

大约50%的患者接受放射治疗作为癌症治疗的一部分。影响放疗后临床预后的最重要因素之一是肿瘤缺氧。低氧水平（缺氧）是肿瘤微环境的一个特征，它会增加转移潜力，并对放疗产生耐药性，从而降低总生存率。然而，即使放射治疗有了进步，包括向质子束治疗（PBT）的发展，缺氧介导的放射抵抗仍然是一个复杂的问题。该项目旨在开发一种技术，实时测量PBT治疗肿瘤的氧气水平，从而测量缺氧。在PBT过程中，剂量通过原子电子的电离和质子与原子核的相互作用沉积在组织中。本项目采用多学科方法，利用PBT过程中自然产生的辐射来测量缺氧。治疗过程中缺氧的实时测量将为适应治疗提供信息，在分级治疗计划中，放射剂量可以升级以克服缺氧放射抵抗。