STRUCTURE AND CONFORMATION OF NOVEL ANTITUMOR AGENTS FROM MARINE ANIMALS

海洋动物新型抗肿瘤剂的结构和构象

• 批准号: 6301808
• 负责人: Phil Crews
• 金额: $ 20.96万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA CRUZ
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6301808
• 关键词: Porifera; alternatives to animals in research; antineoplastics; aquatic organism; bioassay; biological products; chemical structure function; computer simulation; conformation; drug screening /evaluation; mathematical model; nuclear magnetic resonance spectroscopy

This project deals with the discovery of unique marine natural products that may provide leads for the development of anti-cancer agents. Our continuing overall objective is to obtain compounds both fundamentally new molecular structures and potential in anticancer drug development. To effectively address such a broad goal requires a collaborative effort between marine natural products chemistry, cell biology and organism biology. All of these elements are present in the experimental design and in the available facilities. Indo-Pacific marine sponges (sometimes collected by MBRS student participants) are the initial materials used in this research and they are chosen from taxonomic groups that have not been well studied. Their crude extracts are being investigated by a bioassay guided approach. Once compounds are isolated they are characterized by extensively study using such powerful spectroscopic methods as multi-dimensional Nuclear Magnetic Resonance. Each MBRS student will have the option of joining one of three funded, on-going projects. The goal in this MBRS component is to expose students to the major interests of our laboratory including organic structure analysis, elucidation biosynthetic pathways, and uncovering relationships between patterns of organic structure and the phyletics of their organism source. MBRS students interested in biology, biochemistry, or bioorganic chemistry can participate. Students first learn how to organize and track experiments where the correct interpretation of initial results dictates the follow-up experiments. A parallel effort involves learning logical approaches using state-of-the-art NMR methods to solve complex problems of molecular structure analysis and determination of stereochemistry relationships. Another intent is to provide situations where research results can be compared to information obtained from both the biological and chemistry literature to derive new insights about biosynthesis or chemotaxonomy.

这个项目涉及独特的海洋天然产品的发现