STRUCTURE AND CONFORMATION OF NOVEL ANTITUMOR AGENTS FROM MARINE ANIMALS

海洋动物新型抗肿瘤剂的结构和构象

• 批准号: 6301808
• 负责人: Phil Crews
• 金额: $ 20.96万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA CRUZ
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6301808
• 关键词: Porifera; alternatives to animals in research; antineoplastics; aquatic organism; bioassay; biological products; chemical structure function; computer simulation; conformation; drug screening /evaluation; mathematical model; nuclear magnetic resonance spectroscopy

This project deals with the discovery of unique marine natural products that may provide leads for the development of anti-cancer agents. Our continuing overall objective is to obtain compounds both fundamentally new molecular structures and potential in anticancer drug development. To effectively address such a broad goal requires a collaborative effort between marine natural products chemistry, cell biology and organism biology. All of these elements are present in the experimental design and in the available facilities. Indo-Pacific marine sponges (sometimes collected by MBRS student participants) are the initial materials used in this research and they are chosen from taxonomic groups that have not been well studied. Their crude extracts are being investigated by a bioassay guided approach. Once compounds are isolated they are characterized by extensively study using such powerful spectroscopic methods as multi-dimensional Nuclear Magnetic Resonance. Each MBRS student will have the option of joining one of three funded, on-going projects. The goal in this MBRS component is to expose students to the major interests of our laboratory including organic structure analysis, elucidation biosynthetic pathways, and uncovering relationships between patterns of organic structure and the phyletics of their organism source. MBRS students interested in biology, biochemistry, or bioorganic chemistry can participate. Students first learn how to organize and track experiments where the correct interpretation of initial results dictates the follow-up experiments. A parallel effort involves learning logical approaches using state-of-the-art NMR methods to solve complex problems of molecular structure analysis and determination of stereochemistry relationships. Another intent is to provide situations where research results can be compared to information obtained from both the biological and chemistry literature to derive new insights about biosynthesis or chemotaxonomy.

该项目致力于发现独特的海洋天然产物。 这可能为抗癌药物的开发提供线索。我们的 持续的总体目标是从根本上获得化合物 新的分子结构及其在抗癌药物开发中的潜力。 要有效地实现这样一个广泛的目标，需要共同努力。 海洋天然产物化学、细胞生物学和生物体 生物学。所有这些元素都存在于实验设计中 在现有的设施中。印度-太平洋海绵(有时 由MBRS学生参与者收集)是最初使用的材料 在这项研究中，它们是从没有 已经做了很好的研究。他们的粗提物正在接受一个 生物测定指导法。一旦化合物被分离出来，它们就是 以使用如此强大的光谱进行广泛研究为特征的 方法：多维核磁共振。 每个MBRS学生都可以选择加入三个资助项目中的一个， 正在进行的项目。该MBRS组件的目标是让学生 为了我们实验室的主要利益，包括有机结构 分析、阐明生物合成途径和揭示关系 在有机结构的模式和它们的有机体的系统学之间 消息来源。对生物、生物化学或生物有机感兴趣的MBRS学生 化学可以参与其中。学生首先学习如何组织和 跟踪对初始结果进行正确解释的实验 规定了后续实验的方向。并行的努力涉及到学习 使用最先进的核磁共振方法解决复杂问题的逻辑方法 关于分子结构分析和测定的几个问题 立体化学关系。另一个意图是提供各种情况 在那里可以将研究结果与从两者获得的信息进行比较 生物和化学文献，以获得关于 生物合成或化学分类学。