STRUCTURE AND CONFORMATION OF NOVEL ANTITUMOR AGENTS FROM MARINE ANIMALS
海洋动物新型抗肿瘤剂的结构和构象
基本信息
- 批准号:6301808
- 负责人:
- 金额:$ 20.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-04-01 至 2001-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This project deals with the discovery of unique marine natural products
that may provide leads for the development of anti-cancer agents. Our
continuing overall objective is to obtain compounds both fundamentally
new molecular structures and potential in anticancer drug development.
To effectively address such a broad goal requires a collaborative effort
between marine natural products chemistry, cell biology and organism
biology. All of these elements are present in the experimental design
and in the available facilities. Indo-Pacific marine sponges (sometimes
collected by MBRS student participants) are the initial materials used
in this research and they are chosen from taxonomic groups that have not
been well studied. Their crude extracts are being investigated by a
bioassay guided approach. Once compounds are isolated they are
characterized by extensively study using such powerful spectroscopic
methods as multi-dimensional Nuclear Magnetic Resonance.
Each MBRS student will have the option of joining one of three funded,
on-going projects. The goal in this MBRS component is to expose students
to the major interests of our laboratory including organic structure
analysis, elucidation biosynthetic pathways, and uncovering relationships
between patterns of organic structure and the phyletics of their organism
source. MBRS students interested in biology, biochemistry, or bioorganic
chemistry can participate. Students first learn how to organize and
track experiments where the correct interpretation of initial results
dictates the follow-up experiments. A parallel effort involves learning
logical approaches using state-of-the-art NMR methods to solve complex
problems of molecular structure analysis and determination of
stereochemistry relationships. Another intent is to provide situations
where research results can be compared to information obtained from both
the biological and chemistry literature to derive new insights about
biosynthesis or chemotaxonomy.
这个项目涉及独特的海洋天然产品的发现
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Phil Crews其他文献
Phil Crews的其他文献
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{{ truncateString('Phil Crews', 18)}}的其他基金
Merging Marine-Derived Cytotoxic Natural Products With Experimental Therapeutics
将海洋来源的细胞毒性天然产品与实验疗法相结合
- 批准号:
9038079 - 财政年份:2015
- 资助金额:
$ 20.96万 - 项目类别:
Baccalaureate Bridge to the Biomedical Sciences Program (ACCESS)
生物医学科学学士学位桥梁课程 (ACCESS)
- 批准号:
8019656 - 财政年份:2010
- 资助金额:
$ 20.96万 - 项目类别:
Targeted Discovery of Marine-derived Anticancer Leads
海洋源性抗癌先导化合物的靶向发现
- 批准号:
7934265 - 财政年份:2009
- 资助金额:
$ 20.96万 - 项目类别:
Marine Natural Products 2008 Gordon Research Conference
海洋天然产品2008年戈登研究会议
- 批准号:
7388648 - 财政年份:2008
- 资助金额:
$ 20.96万 - 项目类别:
Anticancer Leads from Marine Sponges and Marine Fungi
海洋海绵和海洋真菌的抗癌作用
- 批准号:
6924483 - 财政年份:2005
- 资助金额:
$ 20.96万 - 项目类别:
ACQUISITION OF A VARIAN 600 MHZ HIGH-RESOLUTION NMR: CANCER
采集 VARIAN 600 MHZ 高分辨率 NMR:癌症
- 批准号:
6973775 - 财政年份:2004
- 资助金额:
$ 20.96万 - 项目类别:
Acquisition of a Varian 600 MHz High-Resolution NMR
获取 Varian 600 MHz 高分辨率 NMR
- 批准号:
6803723 - 财政年份:2004
- 资助金额:
$ 20.96万 - 项目类别:
ACQUISITION OF A VARIAN 600 MHZ HIGH-RESOLUTION NMR: BIOCHEMISTRY
采集 VARIAN 600 MHZ 高分辨率 NMR:生物化学
- 批准号:
6973774 - 财政年份:2004
- 资助金额:
$ 20.96万 - 项目类别:
STRUCTURE AND CONFORMATION OF NOVEL ANTITUMOR AGENTS FROM MARINE ANIMALS
海洋动物新型抗肿瘤剂的结构和构象
- 批准号:
6430866 - 财政年份:2001
- 资助金额:
$ 20.96万 - 项目类别: