STRUCTURE AND CONFORMATION OF NOVEL ANTITUMOR AGENTS FROM MARINE ANIMALS

海洋动物新型抗肿瘤剂的结构和构象

• 批准号: 6430866
• 负责人: Phil Crews
• 金额: $ 28.24万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA CRUZ
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6430866
• 关键词: Porifera; alternatives to animals in research; antineoplastics; aquatic organism; bioassay; biological products; chemical structure function; computer simulation; conformation; drug screening /evaluation; mathematical model; nuclear magnetic resonance spectroscopy

This project deals with the discovery of unique marine natural products that may provide leads for the development of anti-cancer agents. Our continuing overall objective is to obtain compounds both fundamentally new molecular structures and potential in anticancer drug development. To effectively address such a broad goal requires a collaborative effort between marine natural products chemistry, cell biology and organism biology. All of these elements are present in the experimental design and in the available facilities. Indo-Pacific marine sponges (sometimes collected by MBRS student participants) are the initial materials used in this research and they are chosen from taxonomic groups that have not been well studied. Their crude extracts are being investigated by a bioassay guided approach. Once compounds are isolated they are characterized by extensively study using such powerful spectroscopic methods as multi-dimensional Nuclear Magnetic Resonance. Each MBRS student will have the option of joining one of three funded, on-going projects. The goal in this MBRS component is to expose students to the major interests of our laboratory including organic structure analysis, elucidation biosynthetic pathways, and uncovering relationships between patterns of organic structure and the phyletics of their organism source. MBRS students interested in biology, biochemistry, or bioorganic chemistry can participate. Students first learn how to organize and track experiments where the correct interpretation of initial results dictates the follow-up experiments. A parallel effort involves learning logical approaches using state-of-the-art NMR methods to solve complex problems of molecular structure analysis and determination of stereochemistry relationships. Another intent is to provide situations where research results can be compared to information obtained from both the biological and chemistry literature to derive new insights about biosynthesis or chemotaxonomy.

这个项目涉及发现独特的海洋天然产品 这可能为开发抗癌药物提供线索。 我们 持续的总体目标是获得化合物， 新的分子结构和抗癌药物开发的潜力。 为了有效地实现这样一个广泛的目标，需要共同努力 海洋天然产物化学、细胞生物学和生物 生物学 所有这些元素都存在于实验设计中 和现有设施。 印度洋-太平洋海绵（有时 由MBRS学生参与者收集）是使用的初始材料 在这项研究中，它们是从没有 被好好研究过了。 它们的粗提物正在由一个 生物测定指导方法。 一旦化合物被分离出来， 其特点是广泛研究使用这种强大的光谱 方法如多维核磁共振。 每个MBRS学生都可以选择加入三个资助项目之一， 进行中的项目。 该MBRS组件的目标是让学生 我们实验室的主要兴趣包括有机结构 分析，阐明生物合成途径，并揭示关系 有机体的结构模式与其生物体的谱系之间的联系 源头 MBRS学生对生物学，生物化学或生物有机感兴趣 化学可以参与。 学生首先学习如何组织和 跟踪实验，正确解释初始结果， 决定了后续的实验 一个平行的努力涉及学习 使用最先进的NMR方法来解决复杂的 分子结构分析和测定中的问题 立体化学关系 另一个目的是提供情况 研究结果可以与从两者获得的信息进行比较， 生物和化学文献，以获得新的见解， 生物合成或化学分类学。