ANTITUMOR FIJIAN SPONGE DERIVED KETIDE AMINO ACIDS

说明： 具有重要生物价值的海绵Jaspis coriacea是常见的 整个印度洋-太平洋，在斐济珊瑚礁特别丰富。这个 苯并酰胺家族的酮-氨基酸是主要的次要成分 珊瑚的代谢物和几种类似物目前是一种很高的 父NCNPDDG授予U19CA52955的优先级，因为其 对MDA-435乳腺癌细胞的细胞毒作用。FIRCA将协助 更详细地检查珊瑚藻属和孟加胺类的努力。 以前的工作已经确定了苯并胺类药物的分布 在珊瑚藻类中发现的样本似乎随着季节和 海绵的地理位置。尽管这种可变性是 既然如此，导致这种情况的因素还不清楚。这项研究 建议将研究在J. 珊瑚科植物作为生态因子的函数。

DESCRIPTION: The biologically important marine sponge Jaspis coriacea is common throughout the Indo-Pacific and is especially abundant in Fiji reefs. The bengamide family of ketide-amino acids are the predominant secondary metabolites of J. coriacea, and several such analogs are presently a high priority of the parent NCNPDDG grant U19CA52955 because of their cytotoxicity against MDA-435 breast tumor cells. This FIRCA will assist the effort to examine J. coriacea and the bengamides in greater detail. Previous work has established that distribution of the types of bengamides found in J. coriacea samples appears to vary with the season and with the geographical location of the sponges. Although this variability is established, the factors that cause it are not understood. The research proposed will examine the chemical variation of the bengamides in J. coriacea as a function of ecological factors.