STRUCTURE & FUNCTION OF ALZHEIMERS AMYLOID BETA AGGREGATES

阿尔茨海默病（AD）是一种破坏性的，渐进的， 以认知能力下降为特征的神经退行性疾病， 尸检，其独特的大脑病理，神经系统缠结， 神经炎斑块 神经炎斑的主要蛋白质成分是 一种被称为淀粉样蛋白_（A_）的肽，通过以下方式与AD机械连接： 由于其前体蛋白（APP）的突变。 的目标 本研究旨在确定A_集料的结构， 精确地确定分子间的相互作用 A_引起的AD相关神经元反应。 另一个目的是 为了表征A_与另外两个相互作用的结构方面， 斑块成分载脂蛋白E（apoE）和apoJ， 在AD脑组织中升高。 分子相互作用的定义 与AD相关的神经元反应有关， 确定药物靶点以减缓或阻断 疾病病理学 质谱技术是至关重要的 他的机械学研究。

Alzheimer's disease (AD) is a devastating, progressive neurodegenerative disease characterized by cognitive decline, and at autopsy, its distinct brain pathologies, neurofibrillary tangles and neuritic plaques. The major protein component of neuritic plaques is a peptide known as amyloid _ (A_), mechanistically linked to AD by virtue of mutations in its precursor protein (APP). The objective of this research is to define the structure of A_ aggregates and precisely determine the molecular interactions responsible for AD-relevant neuronal responses elicited by A_. A further objective is to characterize structural aspects of A_ interactions with two other plaque components, apolipoprotein E (apoE) and apoJ, which are elevated in AD brain tissue. Definition of molecular interactions linked to AD-relevant neuronal responses is essential for identification of drug targets to slow or block the progression of disease pathology. Mass spectrometric techniques are crucial t o t hesemechanistic studies.