STRUCTURE & FUNCTION OF ALZHEIMERS AMYLOID BETA AGGREGATES

阿尔茨海默病(AD)是一种毁灭性的、进行性的 以认知能力下降为特征的神经退行性疾病， 尸检，其独特的脑部病理，神经原纤维缠绕和 神经炎斑块。神经炎斑块的主要蛋白质成分是 一种被称为淀粉样蛋白_(A_)的多肽，通过 其前体蛋白(APP)的突变。的目标是 本研究的目的是定义A_Aggregates的结构和 精确地确定分子间的相互作用 A_1诱发的AD相关神经元反应。另一个目标是 刻画A_与另外两个相互作用的结构特征 斑块成分载脂蛋白E(ApoE)和apoJ，它们是 在阿尔茨海默病脑组织中升高。分子相互作用的定义 与阿尔茨海默病相关的神经元反应有关 确定药物靶点以减缓或阻止疾病的进展 疾病病理学。质谱学技术是关键。 他的机械学研究。

Alzheimer's disease (AD) is a devastating, progressive neurodegenerative disease characterized by cognitive decline, and at autopsy, its distinct brain pathologies, neurofibrillary tangles and neuritic plaques. The major protein component of neuritic plaques is a peptide known as amyloid _ (A_), mechanistically linked to AD by virtue of mutations in its precursor protein (APP). The objective of this research is to define the structure of A_ aggregates and precisely determine the molecular interactions responsible for AD-relevant neuronal responses elicited by A_. A further objective is to characterize structural aspects of A_ interactions with two other plaque components, apolipoprotein E (apoE) and apoJ, which are elevated in AD brain tissue. Definition of molecular interactions linked to AD-relevant neuronal responses is essential for identification of drug targets to slow or block the progression of disease pathology. Mass spectrometric techniques are crucial t o t hesemechanistic studies.