A population-based family study of filaggrin mutations and allergic disease risk in Australia

澳大利亚一项基于人群的丝聚蛋白突变和过敏性疾病风险的家庭研究

• 批准号: nhmrc : 628513
• 负责人: Dr Adrian Lowe
• 金额: $ 20.58万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/population-based-family-risk-australia/78272
• 关键词: population; based; family; study; filaggrin

It is biologically plausible that the association of known environmental risk factors for asthma may be different for genetically susceptible individuals. Few studies have examined the interaction between genetic and environmental factors. that have not considered genetic susceptibility are estimating an average risk of asthma across all genotypes in the population which may not be relevant for a particular sub-group.

在生物学上，哮喘的已知环境危险因素的关联对于遗传易感个体可能是不同的。很少有研究探讨遗传和环境因素之间的相互作用。没有考虑遗传易感性的研究正在估计人群中所有基因型的平均哮喘风险，这可能与特定的亚组无关。