STRUCTURE OF HYPERTROPHIC CENTROSOMES IN HUMAN BREAST TUMORS

人乳腺肿瘤肥大中心体的结构

• 批准号: 6354291
• 负责人: JEFFREY L SALISBURY
• 金额: $ 3.85万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6354291
• 关键词: biomedical resource; computers; epidemiology; human tissue; infection; international health /scientific organization; microscopy; parasitism

This project is focused on the study of the endomembranes systems (the endoplasmic reticulum and peripheric vacuoles) of Giardia, a very primitive unicellular eukaryote. This study is part of a larger project on the endocytotic and intracellular trafficking and protein sorting processes in this organism. There is also interest in the study of the motor system of Giardia because by videomicroscopy we could see that the flagella moves as well as cell body. For this purpose we have collaborated with the NCMIR. Tomographic reconstructions have been performed on Giardia at the NCMIR in order to see the relationship between the endoplasmic reticulum and peripheric vacuoles. Several tomographc reconstructions were obtained while Dr. Attias visited the NCMIR in December, 1996. We have been tracing the outlines of the endoplasmic reticulum and the peripheric vacuoles using XVOXTRACE and have sent the completed reconstructions to Dr. Attias.

本项目主要研究细胞内膜系统 (the内质网和外周空泡）的贾第鞭毛虫，一个非常 原始单细胞真核生物。 这项研究是一个更大的 内吞和细胞内运输与蛋白质 这种生物的分类过程 也有兴趣在 研究贾第鞭毛虫的运动系统，因为通过视频显微镜， 可以看到鞭毛和细胞体一样移动。 为此 我们与NCMIR合作的目的。 断层 在NCMIR对贾第虫进行了重建， 来观察内质网和 外周液泡。 获得了几个断层重建 1996年12月，Attias博士访问了NCMR。 我们一直 追踪内质网和外周的轮廓 空泡使用XVOXTRACE，并已发送完成重建 阿提亚斯医生