PARALLEL PROCESSING RESOURCE FOR BIOMEDICAL SCIENTISTS

生物医学科学家的并行处理资源

• 批准号: 6126303
• 负责人: THOMAS F COLEMAN
• 金额: $ 88.41万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-15 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6126303
• 关键词: biomedical equipment resource; biomedical resource; chemical structure; macromolecule; parallel processing

A multitude of problems exist in biomedical science that are too complex to be solved by experimentation or mainframe power. Among these, the structure of biologically important macromolecules is a preeminent one. Obvious examples are the interferons, the products of all but one proto- oncogene, and all receptors for hormones and other biological messengers. Computation modeling fills the gap left by experimental methods and yields insights into mechanisms and structures. The computational resources described in this proposal are uniquely suited to examine the biological effects of these molecules. More specifically, the aims of the Cornell Theory Center NIH Resource are: o To build on the strengths of the Theory Center to promote collaborative research endeavors among biologists, chemists, physicists, computer scientists, and numerical mathematicians, pushing algorithm developments and software advances that will lay the basis for further advances in biomedical science; o To provide to biomedical researchers access to highly parallel computing environments that have the potential to achieve very high levels of computing power at new levels of flexibility and cost/performance and which are easily duplicated in researchers' laboratories; o To achieve scientific advances in protein folding and the study of other biologically active macromolecules areas that would be impossible without the computing capability of the Resource; o To develop methodologies and assess existing methodologies for writing programs to make portability between parallel systems possible, so that newer and more powerful machines can immediately be put to use; o To broadly disseminate the results both of research conducted on the Resource and technological developments within it; o To use the knowledge gained from developing biomedical molecular structure applications for highly parallel systems to further enhance parallel technology.

生物医学科学中存在着许多问题，这些问题太复杂， 可以通过实验或大型机来解决。 当中分别有 生物学上重要的大分子的结构是一个突出的问题。 明显的例子是干扰素，除了一种原- 癌基因，以及所有激素受体和其他生物信使。 计算建模填补了实验方法留下的差距， 对机制和结构的洞察。 的计算资源 在这个建议中描述的是独特的适合于检查生物 这些分子的影响。 更具体地说，康奈尔大学的目标 理论中心NIH资源是： o以理论中心的优势为基础，促进合作 生物学家、化学家、物理学家、计算机科学家 科学家和数值数学家推动算法的发展 和软件的进步，这将奠定基础， 生物医学科学; 为生物医学研究人员提供高度并行计算的机会 有可能实现非常高水平的环境 计算能力，灵活性和性价比达到新的水平， 很容易在研究人员的实验室里复制; o在蛋白质折叠和其他蛋白质的研究方面取得科学进展。 生物活性大分子区域，如果没有 资源的计算能力; o制定方法并评估现有的写作方法 程序使并行系统之间的可移植性成为可能，因此， 更新，更强大的机器可以立即投入使用， o广泛传播关于《消除对妇女一切形式歧视公约》 （a）该区域内的资源和技术发展; o利用从开发生物医学分子中获得的知识， 为高度并行系统构建应用程序， 并行技术