Integration of transplanted ESNLCs into spinal circuits

描述：（摘要使用）项目IV将研究移植的ESNLCs整合到受损的脊髓回路中。通过使用常规的生理和解剖工具，将在特征良好的脊髓回路中评估ESNLC移植产生的恢复。具体地，恢复肌定向反射将与球脊髓的恢复相关，球脊髓、本体脊髓和肌肉传入投射到脊髓的移植诱导恢复的基质。还将评估用于移植诱导的功能恢复的电路基板，即细胞凋亡。该项目将依赖于与其他项目和核心密切合作的动物损伤/动物核心C，将恢复的生理和解剖学基础与最佳ESNLC治疗策略的行为效应联系起来。

Description: (Abstract use) Project IV will study the integration of transplanted ESNLCs into injured spinal circuits. By the use of conventional physiological and anatomical tools, recovery produced by ESNLC transplants will be assessed in well-characterized spinal circuits. Specifically, the recovery myotactic reflex will be correlated with the recovery of bulbospinal, substrates for transplant induced recovery of bulbospinal, propriospinal and muscle afferent projections to the spinal cord. The circuit substrates for transplant-induced recovery of function will also be evaluated, apoptosis. The project will rely on the Injury/Animal CORE C for animal closely work with the other Projects and Cores to relate physiological and anatomical substrates of recovery with the behavioral effects of an optimal ESNLC treatment strategy.