Integration of transplanted ESNLCs into spinal circuits

项目四将研究移植esncs与损伤脊髓回路的整合。通过使用传统的生理和解剖学工具，ESNLC移植产生的恢复将在特征良好的脊髓回路中进行评估。具体来说，肌致性反射的恢复将与球脊髓的恢复有关，移植基质诱导球脊髓、本体脊髓和肌肉传入投射到脊髓的恢复。移植诱导功能恢复的电路底物也将被评估，细胞凋亡。该项目将依赖于损伤/动物核心C，与其他项目和核心密切合作，将恢复的生理和解剖基础与最佳ESNLC治疗策略的行为效果联系起来。

Description: (Abstract use) Project IV will study the integration of transplanted ESNLCs into injured spinal circuits. By the use of conventional physiological and anatomical tools, recovery produced by ESNLC transplants will be assessed in well-characterized spinal circuits. Specifically, the recovery myotactic reflex will be correlated with the recovery of bulbospinal, substrates for transplant induced recovery of bulbospinal, propriospinal and muscle afferent projections to the spinal cord. The circuit substrates for transplant-induced recovery of function will also be evaluated, apoptosis. The project will rely on the Injury/Animal CORE C for animal closely work with the other Projects and Cores to relate physiological and anatomical substrates of recovery with the behavioral effects of an optimal ESNLC treatment strategy.