A proteome-wide approach to anti-viral immunity and vaccine development

抗病毒免疫和疫苗开发的全蛋白质组方法

• 批准号: nhmrc : 1104329
• 负责人: Prof David Tscharke
• 金额: $ 42.93万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/proteome-wide-approach-vaccine-development/662743
• 关键词: proteome; wide; approach; anti; viral

We know that many parts of viruses are displayed to the immune system, but at present the exact fragments are difficult to predict, we do not know all the genes in our bodies that control this process and we also need better methods to study the way some viruses (e.g. the cold sore virus) avoid detection. This project will study these problems with the overall goal of improving vaccine design, understanding immune deficiency and how viruses fight back against our immune system.

我们知道，病毒的许多部分都展示给免疫系统，但目前很难预测确切的片段，我们不知道我们体内控制这一过程的所有基因，我们也需要更好的方法来研究一些病毒（例如感冒疮病毒）避免检测的方式。该项目将研究这些问题，总体目标是改进疫苗设计，了解免疫缺陷以及病毒如何反击我们的免疫系统。