The cellular basis of sex-specific responses to virus infection

对病毒感染的性别特异性反应的细胞基础

• 批准号: DP190101325
• 负责人: Prof David Tscharke
• 金额: $ 39.57万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190101325
• 关键词: cellular; basis; sex; specific; responses

This project aims to explore how the sex of cells impacts virus infections in culture. To date, the sex of cells in culture has been overlooked as an important source of biological variability, but may be found to affect basic science through to anti-viral drug discovery. Using a model in which a virus can be adapted to grow better in cells of a single sex, this project expects to generate new knowledge about how sex differences impact virus-host interactions. This project expects to provide new insights into sex-based differences in how cells detect and respond to virus infection, and the extent to which the sex of cells impacts viruses in general.

这个项目旨在探索细胞的性别如何影响培养中的病毒感染。到目前为止，培养细胞的性别一直被忽视，因为它是生物多样性的一个重要来源，但可能会被发现通过抗病毒药物的发现来影响基础科学。利用病毒可以在单性别的细胞中更好地生长的模型，该项目希望产生关于性别差异如何影响病毒与宿主相互作用的新知识。该项目希望对细胞如何检测和响应病毒感染以及细胞性别对病毒的总体影响程度的性别差异提供新的见解。