TSLP and dysregulation of anti-viral immunity in atopic dermatitis

特应性皮炎中的 TSLP 和抗病毒免疫失调

• 批准号: nhmrc : 509199
• 负责人: Prof David Tscharke
• 金额: $ 33.61万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tslp-dysregulation-anti-atopic-dermatitis/76289
• 关键词: TSLP; dysregulation; anti; viral; immunity

Eczema (atopic dermatitis) is a frequent allergy in Australia. People with eczema can suffer very severe skin infections with some viruses, including the virus that causes cold sores, but we do not know why this happens. A newly discovered protein called TSLP is now known to be made by skin affected by eczema and there is evidence that TSLP may interfere with the way the body fights viruses. We will examine whether TSLP programs the immune system so that it is less able to fight viruses.

过敏性皮炎（特应性皮炎）是澳大利亚常见的过敏症。湿疹患者可能会遭受一些病毒的非常严重的皮肤感染，包括导致唇疱疹的病毒，但我们不知道为什么会发生这种情况。一种名为TSLP的新发现的蛋白质现在已知是由受湿疹影响的皮肤产生的，有证据表明TSLP可能会干扰身体对抗病毒的方式。我们将研究TSLP是否对免疫系统进行编程，使其对抗病毒的能力降低。