CORE--ANIMAL AND SURGERY SERVICES

这一核心将监督购买、住房和行为 对动物进行测试。此外，6-OHDA诱导的损伤将 在核心总监的监督下进行。其他内容 对计划项目具有普遍重要性的外科手术程序 还将通过核心开发和执行 需求就会出现。在一系列研究中，我们将研究一种替代方案 通过使用渗透剂来改变传统的损伤模式 用于注射6-OHDA的小型泵。外科手术的质量 将通过进行分析来监测工作 神经化学和组织学服务(核心B和C)。这 因此，核心应会大大提高 程序，允许我们集成通过 计划项目的不同组成部分。

This Core will supervise purchasing, housing, and behavioral testing of animals. In addition, 6-OHDA-induced lesions will be conducted under the supervision of the Core Director. Additional surgical procedures of general importance to the Program Project also will be developed and performed through the Core as the need arises. In a series of studies we will examine an alternative to the conventional mode of lesioning by employing an osmotic minipump to administer the 6-OHDA. The quality of the surgical work will be monitored via analyses conducted by the neurochemistry and histology services (Cores B and C). This Core should therefore greatly enhance the productivity of the Program, permitting us to integrate the results obtained by different components of the Program Project.