CORE--ANIMAL AND SURGERY SERVICES

核心——动物和手术服务

• 批准号: 6448234
• 负责人: Alan F Sved
• 金额: $ 20.73万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6448234
• 关键词: 6 hydroxydopamine; Macaca fascicularis; animal colony; biomedical facility; experimental brain lesion; laboratory rat; nervous system disorder diagnosis; neurochemistry; neurosurgery

This Core will supervise purchasing, housing, and behavioral testing of animals. In addition, 6-OHDA-induced lesions will be conducted under the supervision of the Core Director. Additional surgical procedures of general importance to the Program Project also will be developed and performed through the Core as the need arises. In a series of studies we will examine an alternative to the conventional mode of lesioning by employing an osmotic minipump to administer the 6-OHDA. The quality of the surgical work will be monitored via analyses conducted by the neurochemistry and histology services (Cores B and C). This Core should therefore greatly enhance the productivity of the Program, permitting us to integrate the results obtained by different components of the Program Project.

这个核心将监督购买，住房和行为 动物试验。 此外，6-OHDA诱导的病变将 在核心主任的监督下进行。 额外 对计划项目具有普遍重要性的外科手术 也将通过核心开发和执行， 需要出现。 在一系列的研究中，我们将研究一种替代方案， 传统的损伤模式， 用微型泵注射6-羟多巴胺 手术质量 工作将通过分析进行监测， 神经化学和组织学服务（核心B和C）。 这 因此，核心应大大提高生产力， 程序，使我们能够整合获得的结果， 计划项目的不同组成部分。