Impact of Adolescent Nicotine Use on Nicotine Self-Administration in Adulthood

青少年尼古丁使用对成年后尼古丁自我给药的影响

基本信息

  • 批准号:
    9567277
  • 负责人:
  • 金额:
    $ 20.05万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-05-01 至 2020-04-30
  • 项目状态:
    已结题

项目摘要

Project Summary Adolescents appear to be particularly vulnerable to begin using tobacco and other nicotine (NIC)-containing products. NIC exposure during adolescence may have long-lasting effects on adult behavior, promoting continued use of NIC-containing products in adulthood. This is especially important in the context of a potential tobacco regulatory policy limiting NIC content in tobacco products. Will adolescent NIC use impact how adults will respond to low NIC products? Will adolescent use of very low doses of NIC minimize the impact of adolescent exposure to NIC on adult NIC use? Alternatively, might it promote the use of NIC products in adulthood? The goal of the experiments presented in this proposal is to determine, using a rodent model of NIC self-administration (SA), the impact of NIC use during adolescence on the use of very low NIC content (VLNC) cigarettes in adulthood. Embedded in this is whether or not adolescent use of NIC-containing products serves as a gateway to smoking and whether NIC reduction could minimize this risk. The current R21 application is designed around two specific aims. Aim 1 tests the hypothesis that NIC SA during adolescence (either low or standard dose of NIC) increases adult NIC SA, especially at low doses of NIC. To address this question, adolescent male and female rats will be allowed to self-administer a low or a more standard dose of NIC starting in early adolescence and then the NIC dose will be changed when they are adults. The key measure will be amount of NIC SA in adulthood, and how that is altered by different doses of adolescent NIC SA. Aim 2 tests the hypothesis that NIC SA during adolescence (either low or standard dose) increases the motivation to seek NIC in adulthood. This hypothesis will be tested at the end of Aim 1 by examining responding for NIC on a progressive ratio schedule of reinforcement in adult rats that self-administered NIC throughout adolescence and into adulthood. An important component of these experiments is that NIC will be self-administered along with a mildly reinforcing environmental stimulus, to incorporate the reinforcement enhancement actions of NIC, which are an essential behavioral component driving NIC use. These experiments will help understand the potential long-term consequences of adolescent NIC exposure on continued use of NIC-containing products and will have important implications in the context of potential NIC reduction tobacco regulatory policy. This proposal fits with the RFA Research Objective focused on addiction and the characteristics of tobacco products that may impact addiction as well as understanding the behaviors related to tobacco product use. Here we focus on the adolescent exposure to NIC-containing products and on other salient stimuli coupled with NIC delivery in supporting NIC SA or motivation to obtain NIC.
项目摘要 青少年似乎特别容易受到开始使用烟草和其他含尼古丁(NIC) 产品.青少年时期的NIC暴露可能对成人行为产生长期影响, 成年后继续使用含NIC的产品。这一点在以下情况下尤为重要: 限制烟草制品中NIC含量的潜在烟草监管政策。青少年使用NIC是否会影响 成年人对低NIC产品的反应如何?青少年使用极低剂量的NIC是否会使影响最小化 青少年暴露于NIC对成人NIC使用的影响?或者,它是否可以促进NIC产品的使用, 成年了?本提案中提出的实验的目标是使用啮齿动物模型确定 NIC自我管理(SA),青少年时期使用NIC对使用极低NIC内容的影响 (VLNC)成年后的香烟。其中的关键问题是,青少年是否使用含有NIC的产品 作为吸烟的门户,以及减少NIC是否可以最大限度地减少这种风险。目前R21 应用程序是围绕两个具体目标设计的。目的1测试假设,NIC SA在青春期 (低剂量或标准剂量的NIC)增加成人NIC SA,特别是在低剂量的NIC下。为了解决这个 问题,将允许青春期雄性和雌性大鼠自我施用低剂量或更标准剂量的 NIC开始于青春期早期,然后NIC剂量将在他们成年后改变。关键 测量将是成年期NIC SA的量,以及不同剂量的青少年NIC如何改变SA SA.目的2检验青春期的NIC SA(低剂量或标准剂量)增加 成年后寻求NIC的动机。这一假设将在目标1结束时通过检查 在自我给予NIC的成年大鼠中, 整个青春期和成年期。这些实验的一个重要组成部分是,NIC将 自我管理沿着温和强化的环境刺激,以纳入强化 NIC的增强行动,这是推动NIC使用的基本行为组件。这些 实验将有助于了解青少年NIC暴露的潜在长期后果, 继续使用含有NIC的产品,并将在潜在的NIC背景下产生重要影响。 减少烟草管制政策。这项建议符合RFA的研究目标,重点是成瘾 以及可能影响成瘾的烟草产品的特性, 与烟草制品使用有关。在这里,我们重点关注青少年接触含NIC的产品, 在支持NIC SA或获得NIC的动机中与NIC递送相结合的其他显著刺激。

项目成果

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Alan F Sved其他文献

Alan F Sved的其他文献

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{{ truncateString('Alan F Sved', 18)}}的其他基金

Modeling nicotine/THC co-use
模拟尼古丁/THC 的共同使用
  • 批准号:
    10488247
  • 财政年份:
    2021
  • 资助金额:
    $ 20.05万
  • 项目类别:
Modeling nicotine/THC co-use
模拟尼古丁/THC 的共同使用
  • 批准号:
    10299843
  • 财政年份:
    2021
  • 资助金额:
    $ 20.05万
  • 项目类别:
Pre-doctoral Training in Basic Neuroscience
基础神经科学博士前培训
  • 批准号:
    9893988
  • 财政年份:
    2019
  • 资助金额:
    $ 20.05万
  • 项目类别:
INTERACTIONS BETWEEN NICOTINE & OTHER CIGARETTE SMOKE COMPONENTS IN SUPPORTING
尼古丁之间的相互作用
  • 批准号:
    8379280
  • 财政年份:
    2011
  • 资助金额:
    $ 20.05万
  • 项目类别:
INTERACTIONS BETWEEN NICOTINE & OTHER CIGARETTE SMOKE COMPONENTS IN SUPPORTING
尼古丁之间的相互作用
  • 批准号:
    8153494
  • 财政年份:
    2011
  • 资助金额:
    $ 20.05万
  • 项目类别:
CORE--ANIMAL AND SURGERY SERVICES
核心——动物和手术服务
  • 批准号:
    6610373
  • 财政年份:
    2001
  • 资助金额:
    $ 20.05万
  • 项目类别:
CORE--ANIMAL AND SURGERY SERVICES
核心——动物和手术服务
  • 批准号:
    6448234
  • 财政年份:
    2001
  • 资助金额:
    $ 20.05万
  • 项目类别:
CORE--ANIMAL AND SURGERY SERVICES
核心——动物和手术服务
  • 批准号:
    6302746
  • 财政年份:
    2000
  • 资助金额:
    $ 20.05万
  • 项目类别:
CORE--ANIMAL AND SURGERY SERVICES
核心——动物和手术服务
  • 批准号:
    6323411
  • 财政年份:
    2000
  • 资助金额:
    $ 20.05万
  • 项目类别:
CORE--ANIMAL AND SURGERY SERVICES
核心——动物和手术服务
  • 批准号:
    6112192
  • 财政年份:
    1999
  • 资助金额:
    $ 20.05万
  • 项目类别:

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