Risk Factors for Pancreatic Cancer

描述（申请人提供） 胰腺癌是第九大最常见的癌症，但第五 是美国癌症死亡的主要原因。 它是最迅速致命的疾病之一 癌症，1年和5年生存率仅为16%和0.4%。 作为 目前还没有有效的治疗方法，预防是 至关重要 只有年纪大了和吸烟才是好的- 确定的风险因素。 其他风险因素的作用，如管道和 吸烟，咖啡，茶和酒精消费，糖尿病的存在 糖尿病和体力活动尚不清楚。 为了提供更多的信息，我们建议分析这些因素的关联性， 使用先前收集的数据进行胰腺癌风险的特征。 在1962年或1966年（1962/1966年），29 347名男性和女性， 年龄30-79岁，返回健康问卷。 受试者也返回 1977年的一份健康调查问卷 他们提供了广泛的 这两份问卷的资料，包括香烟、烟斗和 吸烟，咖啡，茶和酒精消费，医生诊断 糖尿病和体力活动。 1962/1966年至1993年期间， 受试者死于胰腺癌。 我们要求资金收集另外两个 截至1995年的死亡率数据（考虑到小型医疗机构的成本限制， 赠款计划），使胰腺癌死亡总数达到 估计230。 功效计算显示有足够的功效检测中度 与这些风险因素相关的相对风险增加（1.5-2.5）。 这一大型数据库提供了一个独特且具有成本效益的机会， 检查各种特征的关联，其中大部分是 有患胰腺癌的风险。 这些分析的结果将 对一种高度致命的疾病具有公共卫生意义。

DESCRIPTION (provided by Applicant) Pancreatic cancer is the ninth most commonly occurring cancer, but the fifth leading cause of cancer death in the US. It is one of the most rapidly fatal cancers, with 1- and 5-year survival of only 16 percent and 0.4 percent. As there are currently no effective treatments for this disease, prevention is of paramount importance. Only older age and cigarette smoking are well- established risk factors. The roles of other risk factors, such as pipe and cigar smoking, coffee, tea and alcohol consumption, the presence of diabetes mellitus, and physical activity are unclear. To provide more information, we propose to analyze the associations of these characteristics with pancreatic cancer risk using previously collected data. In 1962 or 1966 (1962/1966), 29,347 men and women, who were free of cancer and aged 30-79 years, returned a health questionnaire. Subjects also returned another health questionnaire in 1977. They provided a wide range of information on these two questionnaires, including data on cigarette, pipe and cigar smoking, coffee, tea and alcohol consumption, physician-diagnosed diabetes mellitus, and physical activity. Between 1962/1966 through 1993, 210 subjects died from pancreatic cancer. We request funds to collect another two years of mortality data through 1995 (given the costs constraints of the small grants program), bringing the total of pancreatic cancer deaths to an estimated 230. Power calculations show adequate power to detect moderate increases in relative risks (1.5-2.5) associated with these risk factors. This large database provides a unique and cost-effective opportunity to examine the associations of various characteristics, most of which are modifiable, with pancreatic cancer risk. Findings from these analyses will have public health significance for a highly fatal disease.