Controversies in Physical Activity and CHD

描述 （申请人提供）冠心病（CHD）是导致 死在美国。 风险因素包括体力活动，这显然是 与低风险相关。 然而，有关该协会的细节是 不太清楚。 我们建议解决两个悬而未决的问题：（1）什么样的模式 体力活动与低风险有关？ (2)做体力活动 和超重对冠心病风险的负面影响程度相同？ 卫生部长最近建议至少积累30 一周中大部分时间进行5分钟的适度体力活动（一种模式 称为"生活方式生理活动"）。 这与此前的 建议进行至少20分钟的剧烈运动 每周连续3次（“结构化锻炼”）。 目前还不清楚是否 "生活方式体力活动"与降低CHD风险有关， 其益处与参与"有系统的运动相若。" 与久坐行为的高流行率相一致， 超重在美国也很高，而且随着时间的推移而增加。 很少有数据 关于身体活跃但超重的人是否有 冠心病发病率与不活动但体重正常的人相当。 鉴于 在那些超重的人中维持减肥的困难，这是很重要的 为了澄清这一点，因为这样的观察将支持放置更多的 除了传统的冠心病风险外， 在评估超重人群的风险状况时， 我们建议分析7，307名无肥胖男性的详细身体活动数据。 冠心病 对男性进行了5年的随访，约500例冠心病患者 开发 我们将研究久坐的男性， "生活方式体育活动"和那些从事"有组织的锻炼。" 我们还将研究冠心病的风险在男性交叉分类，由两个物理 活动和体重。 这一建议，在相对较小的成本，将 提供重要的公共卫生信息。

DESCRIPTION (Provided by Applicant) Coronary heart disease (CHD) is a leading cause of death in the US. Risk factors include physicial activity, which clearly is associated with lower risk. However, details regarding the association are less clear. We propose to address two unresolved issues: (1) What patterns of physical activity are associated with lower risk? (2) Do physical inactivity and overweight adversely affect CHD risk to the same degree? The Surgeon General recently recommended the accumulation of at least 30 minutes of moderate physical activity most days of the week (a pattern referred to as "lifestyle physcal activity"). This contrasts with previous recommendations that prescribe vigorous exercise for at least 20 minutes continuously 3 times a week ("structured exercise"). It is unclear whether "lifestyle physical activity" is associated with reduced CHD risk, and whether the benefit is comparable to engaging in "structured exercise." In tandem with the high prevalence of sedentary behavior, the prevalence of overweight also is high in the US, and increasing over time. Few data are available regarding whether physically active but overweight persons have comparable CHD rates as inactive but normal weight persons. Given the difficulty of maintaining weight loss among those overweight, it is important to clarify this, since such an observation would support placing much more emphasis on physical activity, in addition to traditional coronary risk factors, when assessing the risk profile of those overweight. We propose to analyze detailed physical activity data on 7,307 men free of CHD. Men have been followed for 5 years, and some 500 cases of CHD have developed. We will examine CHD risk among sedentary men, those with "lifestyle physical activity," and those engaging in "structured exercise." We also will examine CHD risk among men cross-classified by both physical activity and body weight. This proposal, at relatively little cost, will provide important information of public health significance.