Risk Factors for Pancreatic Cancer

描述(由申请人提供) 胰腺癌在最常见的癌症中排名第九，但排在第五位。 是美国癌症死亡的主要原因。它是最迅速致命的病毒之一 癌症，1年和5年存活率只有16%和0.4%。AS 目前还没有有效的治疗方法来治疗这种疾病，预防是 最重要的是。只有年龄较大和吸烟才是健康的- 已确定的风险因素。其他风险因素的作用，如管道和 抽雪茄、喝咖啡、喝茶和喝酒，糖尿病的存在 糖尿病和体力活动尚不清楚。 为了提供更多信息，我们建议分析这些 使用以前收集的数据，研究胰腺癌风险的特征。 在1962或1966年(1962/1966)，29,347名男性和女性没有癌症和 年龄30-79岁，交回健康问卷。受试者也回来了 1977年的另一份健康调查问卷。他们提供了广泛的 关于这两份问卷的信息，包括关于香烟、烟斗和 抽雪茄、喝咖啡、喝茶和喝酒，由医生诊断 糖尿病和体力活动。从1962/1966到1993,210 受试者死于胰腺癌。我们申请资金来募集另外两个 1995年前的死亡率数据(考虑到小规模 赠款计划)，使胰腺癌死亡总数达到 估计有230人。功率计算显示有足够的功率来检测中等 与这些风险因素相关的相对风险增加(1.5-2.5)。 这个大型数据库提供了一个独特且经济高效的机会 检查各种特征之间的关联，其中大部分是 可修改的，有胰腺癌风险。这些分析的结果将 对一种高度致命的疾病具有公共卫生意义。

DESCRIPTION (provided by Applicant) Pancreatic cancer is the ninth most commonly occurring cancer, but the fifth leading cause of cancer death in the US. It is one of the most rapidly fatal cancers, with 1- and 5-year survival of only 16 percent and 0.4 percent. As there are currently no effective treatments for this disease, prevention is of paramount importance. Only older age and cigarette smoking are well- established risk factors. The roles of other risk factors, such as pipe and cigar smoking, coffee, tea and alcohol consumption, the presence of diabetes mellitus, and physical activity are unclear. To provide more information, we propose to analyze the associations of these characteristics with pancreatic cancer risk using previously collected data. In 1962 or 1966 (1962/1966), 29,347 men and women, who were free of cancer and aged 30-79 years, returned a health questionnaire. Subjects also returned another health questionnaire in 1977. They provided a wide range of information on these two questionnaires, including data on cigarette, pipe and cigar smoking, coffee, tea and alcohol consumption, physician-diagnosed diabetes mellitus, and physical activity. Between 1962/1966 through 1993, 210 subjects died from pancreatic cancer. We request funds to collect another two years of mortality data through 1995 (given the costs constraints of the small grants program), bringing the total of pancreatic cancer deaths to an estimated 230. Power calculations show adequate power to detect moderate increases in relative risks (1.5-2.5) associated with these risk factors. This large database provides a unique and cost-effective opportunity to examine the associations of various characteristics, most of which are modifiable, with pancreatic cancer risk. Findings from these analyses will have public health significance for a highly fatal disease.