Controversies in Physical Activity and CHD

描述 (由申请者提供)冠心病是导致 美国的死亡事件。风险因素包括体力活动，这显然是 与较低的风险相关。然而，有关该协会的详细信息如下 不太清楚。我们建议解决两个悬而未决的问题：(1)什么模式 体育锻炼与较低的风险有关？(2)缺乏体育锻炼 超重对冠心病风险有同样程度的负面影响吗？ 卫生局局长最近建议积累至少30 一周中大部分时间适度的体力活动分钟(一种模式 被称为“生活方式的生理活动”)。这与之前的情况形成对比 建议进行至少20分钟的剧烈运动 每周连续3次(“结构性锻炼”)。目前还不清楚是否 “生活方式体力活动”与降低冠心病风险有关，以及 其益处可与从事“结构性锻炼”相提并论。 随着久坐行为的高发， 超重在美国也很高，而且随着时间的推移还在增加。很少有数据是 关于体力活动但超重的人是否有 与不活跃但体重正常的人相比，CHD的发病率可比。给定 超重者很难保持减肥，这一点很重要 澄清这一点，因为这样的观察将支持放置更多 除了传统的冠状动脉风险外，还强调体力活动 在评估超重者的风险概况时，这些因素。 我们建议分析7307名自由职业男性的详细体力活动数据 先心病。对男性进行了5年的跟踪调查，约有500例冠心病患者 发展起来的。我们将研究久坐不动的男性，那些患有 “生活方式体育活动”和那些从事“有组织的锻炼”的人。 我们还将检查男性中的冠心病风险，按身体健康状况进行交叉分类 活动量和体重。这项建议，以相对较低的成本，将 提供对公共卫生有重要意义的信息。

DESCRIPTION (Provided by Applicant) Coronary heart disease (CHD) is a leading cause of death in the US. Risk factors include physicial activity, which clearly is associated with lower risk. However, details regarding the association are less clear. We propose to address two unresolved issues: (1) What patterns of physical activity are associated with lower risk? (2) Do physical inactivity and overweight adversely affect CHD risk to the same degree? The Surgeon General recently recommended the accumulation of at least 30 minutes of moderate physical activity most days of the week (a pattern referred to as "lifestyle physcal activity"). This contrasts with previous recommendations that prescribe vigorous exercise for at least 20 minutes continuously 3 times a week ("structured exercise"). It is unclear whether "lifestyle physical activity" is associated with reduced CHD risk, and whether the benefit is comparable to engaging in "structured exercise." In tandem with the high prevalence of sedentary behavior, the prevalence of overweight also is high in the US, and increasing over time. Few data are available regarding whether physically active but overweight persons have comparable CHD rates as inactive but normal weight persons. Given the difficulty of maintaining weight loss among those overweight, it is important to clarify this, since such an observation would support placing much more emphasis on physical activity, in addition to traditional coronary risk factors, when assessing the risk profile of those overweight. We propose to analyze detailed physical activity data on 7,307 men free of CHD. Men have been followed for 5 years, and some 500 cases of CHD have developed. We will examine CHD risk among sedentary men, those with "lifestyle physical activity," and those engaging in "structured exercise." We also will examine CHD risk among men cross-classified by both physical activity and body weight. This proposal, at relatively little cost, will provide important information of public health significance.