EPIDEMIOLOGY OF NON HODGKINS'S LYMPHOMA DATA ANALYSIS

1988年至1995年，主要研究者及其同事在旧金山弗朗西斯科湾区进行了一项非霍奇金淋巴瘤（NHL）的人群病例对照研究，包括近1600例NHL患者和2500多例对照参与者。NHL病例由北方加州癌症中心使用快速病例确认获得，对照参与者使用随机数字拨号和医疗保健融资管理局文件识别。对纳入研究的NHL患者的病理学资料进行了审查，并对本研究进行了分类：1）评价本大型研究中收集的暴露数据与使用工作公式定义的NHL亚型之间的相关性，重点是研究在所有NHL的主要分析中发现的重要风险因素;和2）完成详细分析，以调查NHL风险与职业和化学品暴露（包括橙子剂）、女性生殖和激素暴露之间的关联，支持表明NHL亚型之间存在病因学差异的假设，这些差异可以通过一组独特的相关风险因素来表征。NHL亚型的危险因素的区分将提供重要的线索，以详细分析之间的利益和风险暴露NHL调整潜在的混杂因素和效应修饰。这些数据可能解释了早期NHL研究结果的不一致性，这些研究受到有限样本量和暴露数据的限制。它们还可以提供关于暴露改变Th 1或Th 2途径和淋巴瘤发生过程的作用的重要额外信息。这些数据将被用作一个更大的淋巴瘤湾区研究的初步结果。

A population-based case-control study of non-Hodgkin's lymphoma (NHL) that included nearly 1600 patients with NHL and more than 2500 control participants was conducted by the Principal Investigator and colleagues in the San Francisco Bay Area between 1988 and 1995. NHL cases were obtained using rapid case ascertainment by the Northern California Cancer Center and control participants were identified using random digit dial and the Healthcare Financing Administration files. Pathology materials for the NHL patients included in the study were reviewed and classified of this study are: 1) to evaluate the association between exposure data collected in this large study and subtypes of NHL defined using the Working Formulation with emphasis on the investigation of risk factors found to be of importance in the main analyses of all NHL; and 2) to complete detailed analyses to investigate the association between risk for NHL and occupational and chemical exposures including Agent Orange, reproductive and hormonal exposures among women , support for hypotheses that indicated there are etiologic differences across NHL subtypes that can be characterized by a unique set of associated risk factors. Differentiation of risk factors by NHL subtypes will provide important clues to detailed analyses between exposures of interest and risk for NHL with adjustment for potential confounders and effect modifiers. These data may explain inconsistencies in results from earlier NHL studies constrained by limited sample size and exposure data. They also may provide important additional information about the role of exposures that alter Th1 or Th2 pathways and the process of lymphomagenesis. These data will be used as preliminary results for a larger Bay Area study of lymphoma.