PANCREATIC CANCER CASE CONTROL STUDY IN SAN FRANCISCO

研究者建议在男性中进行一项基于人群的病例对照研究 和女性来检验外分泌腺癌 胰腺和详细的职业史和化学品暴露（在 特别是氯代烃和芳香胺）、饮食、香烟 吸烟、过敏和其他因素。一种新的分子遗传学研究 将进行CYP 2D 6基因位点的多态性研究， 遗传风险因素在香烟代谢中的可能作用- 衍生化学致癌物在胰腺癌的风险。这项研究将 包括所有外分泌胰腺腺癌患者， 年龄在21岁到85岁之间，会说英语或西班牙语， 在六个县的弗朗西斯科湾区确诊时。1000例 在3.5年的病例中，将对1150名对照进行访谈- 确定期。正在进行的快速病例确定方法， 医院出院名单和病理实验室，将被雇用， 在两周内找到研究区域的胰腺癌患者， 诊断.患者的病理切片将由一名资深 加州大学旧金山分校弗朗西斯科的病理学家。 将使用随机数字拨号识别质控品， 按性别和5岁年龄组与病例匹配。每个黑色有两个控件 将获得西班牙裔患者，以获得充分的统计学数据 将获得其他每例患者的把握度和一个对照。 年龄超过65岁的对照组将从以下人员中随机选择： 卫生保健融资管理局，除了那些从 普通民众。将进行结构化的个人面试 由经过培训的访问者在研究对象的家中或方便的地方进行 到主题。面试主题将包括： 职业与化学品和工业接触、饮食、医疗和 过敏史、药物使用、家族史或胰腺癌， 其他相关条件、人口和其他因素。血样 用于遗传学研究的血液将由抽血者在受试者的 木屋.血清将以等分试样储存在-40 ℃下，细胞样本 将用液氮冷冻保存在欧文纪念血液中 银行全血标本也将被储存用于未来的遗传和 生物标记物研究。将使用单变量和 多变量统计，特别注意潜在的 混杂因素。

The investigator propose a population-based, case-control study in men and women to examine hypotheses linking adenocarcinoma of the exocrine pancreas and detailed occupational history and chemical exposures (in particular chlorinated hydrocarbons and aromatic amines), diet, cigarette smoking, allergies, and other factors. A molecular genetic study of polymorphisms at the CYP2D6 gene locus will be conducted to investigate the possible role of genetic risk factors in the metabolism of cigarette- derived chemical carcinogens in pancreatic cancer risk. The study will include all patients with adenocarcinoma of the exocrine pancreas who are between the ages of 21 and 85, who speak English or Spanish, and who live in the six-county San Francisco Bay Area at time of diagnosis. 1000 cases and 1150 controls will be interviewed during the 3.5 year case- ascertainment period. Ongoing rapid case ascertainment methods, using hospital discharge lists and pathology laboratories, will be employed to locate pancreatic cancer patients in the study area within two weeks of diagnosis. Pathology slides for patients will be reviewed by a senior pathologist at the University of California San Francisco (UCSF). Controls will be identified using random digit dial and will be frequency matched to cases by sex and 5-year age group. Two controls for each black and Hispanic patient will be obtained to achieve adequate statistical power and one control will be obtained for each of the other patients. Controls over age 65 years will be randomly selected from the rolls of the Health Care Financing Administration in addition to those chosen from the general population. Structured personal interviews will be conducted by trained interviewers in study subjects' homes or at a place convenient to the subject. Interview topics will include: detailed information on occupations and chemical and industrial exposures, diet, medical and allergy history, medication use, family history or pancreatic cancer and other relevant conditions, demographic and other factors. Blood samples for genetic investigation will be drawn by phlebotomists in the subjects' homes. Serum will be stored in aliquots at -40 degrees and cell samples will be stored frozen with liquid nitrogen in the Irwin Memorial Blood Bank. Whole blood specimens also will be stored for future genetic and biomarker studies. Analyses will be conducted using univariate and multivariate statistics with careful attention paid to potential confounders.