MATERNAL ENTRAINMENT OF INFANT CIRCADIAN RHYTHM

母亲对婴儿昼夜节律的影响

• 批准号: 6318046
• 负责人: KAREN A. THOMAS
• 金额: $ 8.63万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6318046
• 关键词: adult human (21+); behavioral /social science research tag; body temperature; body temperature regulation; circadian rhythms; clinical research; developmental psychology; female; hormone regulation /control mechanism; human subject; maternal behavior; melatonin; mother /infant health care; mother child interaction; neuropsychology; newborn human (0-6 weeks); patient monitoring device; personal log /diary; sleep; sleep deprivation; statistics /biometry; training; urinalysis; wakefulness; women's health

DESCRIPTION: (provided by applicant) The candidate's long-term goal is to develop interventions that assist parents in shaping their young infants' sleep-wake patterns. The immediate goal is to expand current research involving infant biorhythm into a program of research that includes the simultaneous study of both maternal and infant circadian rhythms and maternal entrainment of the infant's developing rhythm. To achieve these goals, a focused research career development plan is proposed, including intensive study of (1) melatonin in relation to sleep-wake pattern, (2) adult circadian rhythms, and (3) advanced statistics for the study of biorhythms. Infant sleep problems are the primary concern of new parents. Establishment of a 24-hour, day-night pattern is a critical infant milestone that promotes sleep and facilitates family functioning. The importance of maternal entrainment of infants has been established in animal research; however, few studies have examined the role of maternal entrainment in human infants. The circadian rhythms of sleep-wake, temperature, and melatonin are intricately related. The purpose of the proposed research is to explore the relations between maternal and infant circadian rhythms during early infant life. Specific aims include characterizing the mesor, amplitude and acrophase of maternal and infant temperature circadian rhythms, and determining maternal and infant sleep-wake as well as maternal urinary melatonin patterns. Additionally, the phase relationships between mother and infant rhythms will be examined. Forty mother-infant pairs will be studied over a 24-hour period using an intensive within-subject design. Mothers will be 18-40 years of age and have no current illness or major health problems. Infants will be term gestation, 3-10 weeks postnatal age, singleton birth, with no major health problems or current illness. Maternal rectal temperature and infant insulated abdominal skin and axillary temperature will be recorded at one-minute intervals using battery operated monitors. Maternal and infant sleep-wake states will be entered in 15-minute epochs on a sleep-wake record by the mother. Maternal urinary 6-sulfatoxymelatonin will be assayed from samples of each maternal voiding. Cosinor analysis will be used to ascertain cycle parameters. The phase angle separating maternal and infant acrophase will be examined using circular-circular correlation.

描述：（由申请人提供）候选人的长期目标是 制定干预措施，帮助父母塑造幼儿的 睡眠-觉醒模式。近期目标是扩大目前的研究， 婴儿生物节律纳入一项研究计划，其中包括同时 母婴昼夜节律和母亲夹带的研究 婴儿的发育节律。为了实现这些目标，一项有针对性的研究 提出了职业发展计划，包括深入研究（1）褪黑素 与睡眠-觉醒模式有关，（2）成人昼夜节律，和（3） 研究生物节律的先进统计学。婴儿睡眠问题是 初为人父母者的首要问题。建立24小时昼夜模式 是一个重要的婴儿里程碑，促进睡眠，方便家庭 功能母亲携带婴儿的重要性一直是 在动物研究中建立;然而，很少有研究研究了 人类婴儿的母亲夹带。睡眠-觉醒的昼夜节律， 温度和褪黑激素有着错综复杂的关系。建议的目的 研究的目的是探讨母婴昼夜节律之间的关系， 在婴儿早期的生活节奏。具体目标包括： 母婴体温昼夜节律的中位、振幅和顶相 节律，并确定产妇和婴儿的睡眠-觉醒以及产妇 尿褪黑激素模式此外，相位关系 将检查母亲和婴儿的节律。将有40对母婴 在24小时内使用密集的受试者内设计进行研究。母亲 年龄在18-40岁之间，目前没有疾病或重大健康问题 问题婴儿为足月妊娠，出生后3-10周龄，单胎 出生，没有重大健康问题或目前的疾病。母体直肠 温度和婴儿隔热腹部皮肤和腋窝温度将 使用电池操作的监视器以一分钟的间隔记录。产妇 婴儿的睡眠-觉醒状态将在15分钟内进入， 母亲的睡眠记录。孕妇尿中6-硫酸氧褪黑激素 从每次母亲排尿的样品中测定。将使用余弦分析来 确定周期参数。母婴分离的相位角 将使用循环-循环相关来检查顶相。