Contribution of circadian rhythm and maternal entrainment to infant regulation

昼夜节律和母亲牵引对婴儿调节的贡献

• 批准号: 8238131
• 负责人: KAREN A. THOMAS
• 金额: $ 21.69万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8238131
• 关键词: Address; Affect; Age; Attention; Behavior; Behavioral; Bioperiodicity; Birth; Characteristics; Child; Circadian Dysregulation; Circadian Rhythms; Code; Cognitive; Cues; Development; Emotional; Emotions; Environment; Event; Exhibits; Failure; Fatigue; Foundations; Home environment; Hour; Human; Hypersensitivity; Infant; Infant Development; Infant Health; Intervention; Investigation; Laboratories; Life; Light; Measurement; Measures; Melatonin; Mental Depression; Mental Health; Mothers; Neuraxis; Parents; Pattern; Physical activity; Physiological; Process; Publishing; Questionnaires; Regulation; Research; Risk; Role; Salivary; Sampling; Self-control as a personality trait; Sensory; Shapes; Sleep; Symptoms; System; Temperament; Time; Toddler; Touch sensation; Video Recording; Weight Gain; actigraphy; base; caregiving; feeding; gaze; longitudinal design; physical conditioning; social; vocalization

DESCRIPTION (provided by applicant): Physiological rhythm is central to establishment of interactive synchrony between mothers and infants and subsequently interactive synchrony is the foundation for development of infant regulation. Few studies have associated developing infant circadian rhythm and maternal entrainment with maternal-infant interactive synchrony and subsequent infant regulation. Feeding difficulties, disrupted sleep-wake pattern, and altered maternal-infant interaction are characteristic of dysregulated infants. The purpose of the proposed research is to characterize the l trajectory of infant circadian rhythm development, examine early synchrony of maternal and infant circadian rhythm and interaction, and predict infant regulation based on rhythm and interactive synchrony. Primary Aims include: (1) Determine the longitudinal pattern of maternal and infant circadian rhythm timing and strength as measured by cycle acrophase, amplitude, and cosinor fit (R2) of actigraphy recordings performed at 4, 8, and 12 weeks infant age. (2) Explore longitudinally environmental influences (light, home routine) on entrainment of circadian rhythm as measured by maternal and infant salivary melatonin circadian rhythm assessed at 4, 8, and 12 weeks infant age. (3) Examine the longitudinal pattern of maternal- infant physiological synchrony defined as the separate correlations between mother and infant circadian rhythm (CR-CORR) parameters (acrophase, amplitude, and cosinor fit) derived from actigraphy recordings performed at 4, 8, and 12 weeks infant age. (4) Assess the prediction of (a) maternal-infant interactional synchrony (CO-ACT), as measured by proportion of coordinated gaze, vocalization, and touch at 12 weeks, and (b) infant physiological and emotional regulation as measured by Infant/Toddler Symptom Checklist (ITSC), Laboratory Temperament Assessment Battery (Lab-TAB), and Brief Infant Sleep Questionnaire (BISQ) at 32 weeks infant age, using maternal-infant physiological synchrony (CR-CORR) as predictor. Forty healthy mother-infant pairs will be studied using a longitudinal design with times of measure at 4, 8, 12, and 32 weeks infant age. At 4, 8, and 12 weeks circadian rhythm of activity will be determined in the home using actigraphy recordings, combined with measurement of environmental light, and salivary samples will be collected serially throughout a 24-hour day to assess melatonin rhythm. At 12 weeks face-to-face affect synchrony (CO-ACT) will be coded from a 5 minute video recording of mother-infant interaction. At 32 weeks infant regulation will be assessed using the Laboratory Temperament Assessment Battery (Lab-TAB), Infant/Toddler Symptom Checklist (ITSC), and Brief Infant Sleep Questionnaire (BISQ) and maternal sleep and wake disturbance, depression, and fatigue as well as home routine will be assessed. Circadian rhythm will be derived from cosinor analysis. Cosinor parameters (acrophase, amplitude, cosinor fit) will be correlated (CR-CORR). Maternal-infant physiological synchrony (CR-CORR) will be used to predict interactive synchrony at 12 weeks and infant regulation at 32 weeks. PUBLIC HEALTH RELEVANCE: This project involves circadian rhythm in mothers and their young infants and will examine the influence of synchrony between mother and infant physiological rhythms on maternal-infant interaction and infant regulation. Circadian rhythm of mother and infant activity and melatonin will be determined and correlated with mother and infant face-to-face behavior during interaction and with later infant emotional and behavioral regulation. Early coordination of mother and infant physical activity is theorized to affect infant sleep-wake pattern and behavioral and emotional responsiveness.

描述（由申请人提供）：生理节律对于建立母亲和婴儿之间的互动同步性至关重要，随后互动同步性是婴儿调节发展的基础。很少有研究将婴儿昼夜节律的发育和母亲的牵引与母婴互动同步性和随后的婴儿调节联系起来。喂养困难、睡眠-觉醒模式紊乱以及母婴互动改变是失调婴儿的特征。本研究的目的是表征婴儿昼夜节律发育的轨迹，检查母婴昼夜节律的早期同步性和相互作用，并根据节律和相互作用同步性预测婴儿的调节。主要目标包括：(1) 确定母婴昼夜节律时间和强度的纵向模式，通过在 4、8 和 12 周婴儿龄进行的体动记录仪记录的周期末相、振幅和余弦拟合 (R2) 来测量。 (2) 纵向探索环境（光、家庭日常活动）对昼夜节律的影响，通过在 4、8 和 12 周婴儿龄时评估的母婴唾液褪黑激素昼夜节律来测量。 (3) 检查母婴生理同步的纵向模式，定义为母亲和婴儿昼夜节律 (CR-CORR) 参数（顶相、振幅和余弦拟合）之间的单独相关性，这些参数源自 4、8 和 12 周婴儿龄的体动记录仪记录。 (4) 评估 (a) 母婴互动同步性 (CO-ACT) 的预测，通过 12 周时协调凝视、发声和触摸的比例进行测量，以及 (b) 婴儿生理和情绪调节，通过婴儿/幼儿症状检查表 (ITSC)、实验室气质评估组 (Lab-TAB) 和简短婴儿睡眠问卷 (BISQ) 在 32 周时测量 婴儿年龄，使用母婴生理同步性（CR-CORR）作为预测因子。将使用纵向设计对 40 对健康母婴进行研究，测量时间为 4、8、12 和 32 周婴儿龄。在第 4、8 和 12 周时，将在家中使用体动记录并结合环境光测量来确定活动的昼夜节律，并在一天 24 小时内连续收集唾液样本以评估褪黑激素节律。 12 周时，面对面情感同步 (CO-ACT) 将从 5 分钟的母婴互动视频中编码。 32 周时，将使用实验室气质评估套组 (Lab-TAB)、婴儿/幼儿症状检查表 (ITSC) 和婴儿睡眠简短问卷 (BISQ) 评估婴儿调节能力，并评估产妇睡眠和觉醒障碍、抑郁和疲劳以及家庭日常生活。昼夜节律将从余弦分析中得出。余弦参数（末相、振幅、余弦拟合）将相互关联 (CR-CORR)。母婴生理同步性 (CR-CORR) 将用于预测 12 周时的交互同步性和 32 周时的婴儿调节。 公共卫生相关性：该项目涉及母亲及其幼儿的昼夜节律，并将研究母亲和婴儿生理节律的同步性对母婴互动和婴儿调节的影响。母亲和婴儿的活动和褪黑激素的昼夜节律将被确定，并与母亲和婴儿在互动过程中面对面的行为以及随后的婴儿情绪和行为调节相关。理论上，母亲和婴儿身体活动的早期协调会影响婴儿的睡眠-觉醒模式以及行为和情绪反应。