TRAINING OF ARTHRITIS RESEARCH SCIENTISTS

描述（来自申请）：这是一个流变学培训补助金的竞争性续期申请，最后一次资助是在1976年。 该培训计划的目标是准备合格的个人职业生涯作为独立的研究人员在基础和临床研究领域与风湿性疾病的问题。合格的医学博士候选人通常已经完成了流变学的临床培训，并且必须表现出对研究和学术生涯的浓厚兴趣。符合条件的博士候选人将获得博士学位。分子遗传学，生物化学，细胞生物学，免疫学或生命科学相关领域的学位。培训计划包括一系列结构化的基础科学讲座和研究会议，旨在为学员提供生物科学相关领域的概念框架。M.D.学员还将申请参加密歇根大学医学院提供的为期三个月的全日制强化研究培训课程。实验室培训期将包括至少两年的研究经验，最低限度的同时临床承诺。 所有学员将申请外部资助的个人研究金，培训方案将用于支持学员一到两年，直到他们能够获得外部资金。该培训项目的教师导师包括18名医学博士，博士M.D.博士密歇根大学医学院的终身教职科学家。这些教师中有11人在流变学部任命，7人来自其他部门或部门。一些教师在临床和基础科学部门联合任命。培训计划还得到了与临床职责（终身教职和非终身教职）合作的教师以及与非终身教职任命的研究教师的支持。合作教师将参加培训计划，但不会担任学员的主要导师。由教师导师代表的科学专业知识领域包括免疫学，生物化学，细胞生物学和分子遗传学，在与风湿性疾病当前问题相关的调查领域。这些研究项目得到了超过800万美元的外部研究资金和超过22，000平方英尺的实验室空间的支持。培训计划受益于密歇根大学多功能关节炎中心和风湿性关节炎专业研究中心的支持。与免疫病理学，老年病学和细胞与分子生物学的培训课程有密切的互动。在过去十年中，对招聘优秀女性和少数民族受训人员的重视已使这些人毕业并担任学术职务，这一重视将继续下去。密歇根大学的流变学培训计划在学术流变学和相关基础研究领域的领导者方面有着良好的记录。当前提案中概述的教师、设施和培训计划应为扩大这些成就提供一个良好的框架。

DESCRIPTION (from the application): This is a competitive renewal application for a Rheumatology Training Grant that was last funded in 1976. The goal of this Training Program is to prepare qualified individuals for careers as independent investigators in areas of basic and clinical research related to problems in rheumatic diseases. Eligible M.D. candidates will generally have completed their clinical training in Rheumatology and must demonstrate a strong interest in research and in an academic career. Eligible Ph.D. candidates will have received their Ph.D. degree in Molecular Genetics, Biochemistry, Cell Biology, Immunology, or a related area of the life sciences. The Training Program includes a structured series of basic science lectures and research conference designed to give trainees a conceptual framework in the relevant areas of biological sciences. M.D. trainees will also apply to be enrolled in a three month full time, intensive research training course offered by the University of Michigan Medical School. The laboratory training period will include at least two years of research experience, with minimum concurrent clinical commitments. All trainees will apply for individual externally funded fellowships, and the Training Program will be used to support trainees for one to two years until they are able to obtain external funding. The faculty mentors for this Training Program include eighteen M.D., Ph.D. and M.D./Ph.D. scientists with tenure track faculty appointment at the University of Michigan Medical School. Eleven of these faculty members have appointments in the Division of Rheumatology and seven are from other departments or divisions. Several faculty members have joint appointments in both clinical and basic science departments. The Training Program is also supported by collaborating faculty with clinical duties (both tenure track and non-tenure track), and by research faculty with non-tenure track appointments. The collaborating faculty will participate in the Training Program but will not serve as primary mentors for trainees. The areas of scientific expertise represented by the faculty mentors include immunology, biochemistry, cell biology, and molecular genetics, in fields of investigation related to current problems in rheumatic diseases. These research programs are supported by external research funding greater than $8 million and by more than 22,000 square feet of laboratory space. The Training Program benefits greatly from support of the University of Michigan Multipurpose Arthritis Center and the Specialized Center of Research in Rheumatoid Arthritis. There is close interaction with the training programs in Immunopathology, Geriatrics and Cellular and Molecular Biology. Emphasis over the past ten years on recruitment of outstanding female and minority trainees has resulted in graduation of such individuals into academic positions, and this emphasis will be continued. The University of Michigan Training Program in Rheumatology has a strong record of producing leaders in academic rheumatology and related areas of basic investigation. The faculty, facilities and training plan outlined in the current proposal should provide an excellent framework for augmenting these accomplishments.