Training of Arthritis Research Scientists

描述（由申请人提供）：这是一个修订后的竞争性更新申请的流变学培训补助金，首次资助于1976年，其目的是准备合格的个人的职业生涯作为独立的研究人员在基础和临床研究领域有关的风湿性疾病的问题。合格的医学博士候选人已经完成了成人或儿科流变学的大部分临床培训，并表现出对研究和学术生涯的浓厚兴趣。符合条件的博士候选人已获得博士学位。在生命科学的相关领域的学位，并寻求专注于风湿性疾病研究的职业生涯。培训计划包括一系列结构化的基础科学讲座和研究会议，旨在为学员提供生物科学相关领域的概念框架，并通过基础，转化和临床研究相关领域的额外必修课程工作进行补充。研究培训期包括至少两年的研究经验，同时临床承诺最少。培训项目的教师导师包括24名医学博士，哲学博士、M.D.博士在密歇根大学，有终身教职的调查人员，其中11人在流变学系任职，12人在其他系或系任职，1人在流变学和老年医学。培训计划还得到了具有临床和研究职责（终身教职和非终身教职）的合作教师的支持，他们参加了培训计划，但不会担任学员的主要导师。代表的科学专业领域包括免疫学、细胞和分子生物学以及风湿性疾病的临床研究。风湿病科的研究项目得到了大量外部研究资金的支持，超过11，000平方英尺的实验室空间，以及最近更新到2011年的密歇根大学风湿病核心中心。该培训计划在学术流变学和相关领域的领导者中具有良好的记录。本提案中概述的教师、设施和培训计划将为扩大这些成就提供一个很好的框架。

DESCRIPTION (provided by applicant): This is a revised resubmission of a competitive renewal application for a Rheumatology Training Grant that was first funded in 1976, and that aims to prepare qualified individuals for careers as independent investigators in areas of basic and clinical research related to problems in rheumatic diseases. Eligible M.D. candidates have completed most of their clinical training in adult or pediatric Rheumatology and demonstrate a strong interest in research and in an academic career. Eligible Ph.D. candidates have received a Ph.D. degree in a relevant area of the life sciences, and seek to focus their career on rheumatic disease research. The Training Program includes a structured series of basic science lectures and research conferences designed to give trainees a conceptual framework in the relevant areas of biological science, and this is supplemented by additional required course work in relevant areas of basic, translational and clinical research. The research training period includes at least two years of research experience, with minimal concurrent clinical commitments. The faculty mentors for the Training Program include 24 M.D., Ph.D., and M.D./Ph.D. investigators with tenure track faculty appointments at the University of Michigan, eleven of whom have appointments in the Division of Rheumatology, twelve in other Departments or Divisions, and 1 in both Rheumatology and Geriatrics. The Training Program is also supported by collaborating faculty with clinical and research duties (both tenure track and non-tenure track), who participate in the Training Program, but will not serve as primary mentors for trainees. The areas of scientific expertise represented include immunology, cell and molecular biology, and clinical investigation in the rheumatic diseases. The research programs of the Division of Rheumatology are supported by substantial external research funding, by more than 11,000 square feet of laboratory space, and by the University of Michigan Rheumatic Diseases Core Center which was recently renewed through 2011. This Training Program has a strong record of producing leaders in academic rheumatology and related fields. The faculty, facilities, and training plan outlined in this proposal will provide an excellent framework for augmenting these accomplishments.