Training of Arthritis Research Scientists

关节炎研究科学家的培训

• 批准号: 8703009
• 负责人: David Alan Fox
• 金额: $ 24.07万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8703009
• 关键词: Arthritis; Research; Scientist; Training

DESCRIPTION (provided by applicant): This is a revised application for a Rheumatology Training Grant at the University of Michigan that aims to prepare qualified individuals for careers as independent investigators in basic, translational or clinical research in systemic rheumatic diseases. The proposed Training Program Director is Dr. Alisa Koch, an experienced scientist and mentor, who will be assisted by Drs. David Fox and Mariana Kaplan. Trainees will focus on clinical, translational or basic research related to rheumatic diseases. Eligible M.D. candidates will have completed most of their clinical training in adult or pediatric Rheumatology and must demonstrate a strong interest in research and in an academic career. Eligible Ph.D. candidates, with a degree in a relevant area of the life sciences, must seek to focus their career on rheumatic disease research. The Training Program includes a structured series of basic science lectures and research conferences designed to give trainees a conceptual framework in the relevant areas of science, and a thorough understanding of the disease entities related to their research project. This is supplemented by additional required course work in relevant areas of basic, translational and clinical research. The research training period includes at least two years of research experience, with minimal concurrent clinical commitments. The faculty mentors for the Training Program include 21 M.D., Ph.D., and M.D./Ph.D. investigators with tenure track faculty appointments at the University of Michigan, 10 of whom are in the Division of Rheumatology, nine in other Departments or Divisions, and one in both Rheumatology and Geriatrics. The areas of scientific expertise represented include immunology and inflammation, cell and molecular biology, and clinical investigation in the rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus (SLE), scleroderma (SSc), and fibromyalgia. These faculty have a strong record of discovery in areas such as the molecular basis of autoimmunity, the role of angiogenesis in inflammation, interactions between immune cells and tissue cells that lead to end-organ damage, vascular complications of autoimmune disease, and clinical investigations in SLE, SSc and fibromyalgia. The research programs of the Training Program are supported by substantial external research funding, more than 20,000 square feet of laboratory space, the University of Michigan Rheumatic Diseases Core Research Center, and large cohorts of patients with systemic rheumatic diseases. This Division of Rheumatology has a strong record of producing leaders in academic rheumatology and related fields. The faculty, facilities, and training plan outlined in this proposal will provide an outstanding framework for augmenting these accomplishments.

描述(由申请人提供)：这是密歇根大学风湿病培训助学金的修订申请，旨在为职业生涯准备合格的个人 作为系统性风湿病基础、翻译或临床研究的独立研究人员。拟议的培训计划主任是经验丰富的科学家和导师Alisa Koch博士，他将得到David Fox博士和Mariana Kaplan博士的协助。受训人员将专注于与风湿病相关的临床、翻译或基础研究。符合条件的医学博士候选人将完成其成人或儿科风湿病学的大部分临床培训，并必须对研究和学术生涯表现出浓厚的兴趣。拥有生命科学相关领域学位的符合条件的博士候选人必须寻求专注于风湿病研究。培训计划包括一系列有组织的基础科学讲座和研究会议，旨在为受训者提供相关科学领域的概念框架，并彻底了解与其研究项目相关的疾病实体。除此之外，还有基础、翻译和临床研究相关领域的额外必修课工作。研究培训期包括至少两年的研究经验，同时临床承诺最少。该培训项目的教师导师包括21名医学博士、博士和医学博士/博士研究员，他们的终身教职跟踪密歇根大学的教职任命，其中10人在风湿科，9人在其他系或科，1人在风湿病学和老年病学。代表的科学专长领域包括免疫学和炎症、细胞和分子生物学，以及风湿性疾病的临床研究，包括类风湿性关节炎、系统性红斑狼疮(SLE)、硬皮病(SSC)和纤维肌痛。这些教师在自身免疫的分子基础、血管生成在炎症中的作用、免疫细胞与导致终末器官损害的组织细胞之间的相互作用、自身免疫性疾病的血管并发症以及SLE、SSC和纤维肌痛的临床研究等领域有着丰富的发现记录。培训计划的研究项目得到了大量外部研究资金、超过20,000平方英尺的实验室空间、密歇根大学风湿病核心研究中心和大量系统性风湿病患者的支持。风湿病学部在风湿病及相关领域的学术领袖方面有着很好的记录。本提案中概述的师资、设施和培训计划将为扩大这些成就提供一个出色的框架。