K24 MID-CAREER CLINICAL INVESTIGATOR AWARD

描述(改编自申请摘要)：约翰·A·巴特利特寻求 K24职业中期调查员奖，以增加他的表演机会 以患者为导向的研究，并指导进入职业生涯的新调查人员 临床调查。如果巴特利特博士获得这个奖项，他将减少 他的病人护理责任减少到每周半天，他将收到 来自劳埃德·爱德华兹博士的生物统计学合作。巴特利特博士的研究 重点关注艾滋病毒的发病机制和抗逆转录病毒治疗，特别是 翻译，由调查员发起的项目。他近期的研究 目标包括调查抗逆转录病毒治疗失败的情况，以及 努力减少人体内慢性艾滋病毒感染细胞的蓄积量 接受抗逆转录病毒治疗。他的长期职业目标集中在 继续纳入关于艾滋病毒发病机制的科学观察 转化为改进的抗逆转录病毒治疗策略。巴特利特博士与 与杜克大学的其他基础和临床科学研究人员广泛合作 通过ACTG、CFAR、SPIRAT和GCRC奖以及他的研究 这些努力将由一个科学咨询委员会指导。巴特利特医生有 立即接触1058名感染艾滋病毒的成人和109名感染艾滋病毒的儿童 之后在杜克大学学习。他成功地指导了许多临床医生 调查人员，包括参与当前项目的调查人员。这些 指导活动得到新闻部领导层的大力支持 医学部和传染病科，以及艾滋病培训 格兰特，它为年轻的调查人员提供财政支持。

DESCRIPTION (adapted from application's abstract): John A. Bartlett seeks the K24 Mid-Career Investigator Award to enhance his opportunity to perform patient-oriented research, and mentor new investigators entering a career of clinical investigation. If Dr. Bartlett receives this award he will decrease his patient care responsibilities to 1/2 day per week, and he will receive biostatistical collaboration from Dr. Lloyd Edwards. Dr. Bartlett's research focuses on HIV pathogenesis and antiretroviral therapies, especially translational, investigator-initiated projects. His immediate research objectives include the investigation of antiretroviral treatment failure, and efforts to diminish the reservoir of chronically HIV-infected cells in persons receiving antiretroviral therapy. His long-term career objective centers on the continued incorporation of scientific observations on HIV pathogenesis into improved antiretroviral treatment strategies. Dr. Bartlett collaborates extensively with other basic and clinical sciences investigators at Duke University through ACTG, CFAR, SPIRAT and GCRC Awards, and his research efforts will be guided by a Scientific Advisory Committee. Dr. Bartlett has immediate access to 1058 HIV-infected adults and 109 HIV infected children followed at Duke University. He has successfully mentored numerous clinical investigators, including investigators involved with current projects. These mentorship activities are strongly supported by leadership of the Department of Medicine and the Division of Infectious Diseases, and an AIDS Training Grant, which provides financial support for young investigators.