MUTATION AND RECOMBINATION OF RETROVIRUSES
MUTATION AND RECOMBINATION OF RETROVIRUSES
批准号:
6376250
负责人:
JIAYOU ZHANG
金额:
$10.57万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-08-01 至 2003-07-31
关键词:
DNA directed RNA polymerase DNA replication RNA directed DNA polymerase enzyme activity frameshift mutation genetic recombination human immunodeficiency virus microorganism culture murine leukemia virus nucleic acid sequence nucleic acid structure transfection /expression vector virus DNA virus RNA virus genetics virus replication
中文摘要
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英文摘要
DESCRIPTION: Dr. Zhang proposes to compare the rate of mutation in vivo
during first and second strand DNA synthesis. He will utilize an in vitro
assay to compare the frameshift rates of RNA polymerase II, RT first strand,
and RT second strand synthesis. He will test the three prevailing models
for how recombination occurs in retroviruses using in vivo and in vitro
systems. He will also test the effects of RNA secondary structure on
stimulation of recombination.
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Photoelectron microscopy and immunofluorescence microscopy of cytoskeletal elements in the same cells.
同一细胞中细胞骨架元件的光电子显微镜和免疫荧光显微镜。
DOI:
10.1073/pnas.80.13.4012
发表时间:
1983
期刊:
Proceedings of the National Academy of Sciences of the United States of America
影响因子:
11.1
作者:
[Nadakavukaren,KK, Chen,LB, Habliston,DL, Griffith,OH]
通讯作者:
Griffith,OH
Retroviral recombination is temperature dependent.
逆转录病毒重组具有温度依赖性。
DOI:
10.1099/0022-1317-82-6-1359
发表时间:
2001
期刊:
The Journal of general virology
影响因子:
--
作者:
[Li,Ting, Zhang,Jiayou]
通讯作者:
Zhang,Jiayou
Evidence for retroviral intramolecular recombinations.
逆转录病毒分子内重组的证据。
DOI:
10.1128/jvi.75.14.6348-6358.2001
发表时间:
2001
期刊:
Journal of virology
影响因子:
5.4
作者:
[Zhang,J, Ma,Y]
通讯作者:
Ma,Y
Host RNA polymerase II makes minimal contributions to retroviral frame-shift mutations.
宿主 RNA 聚合酶 II 对逆转录病毒移码突变的贡献微乎其微。
DOI:
10.1099/vir.0.80081-0
发表时间:
2004
期刊:
The Journal of general virology
影响因子:
--
作者:
[Zhang,Jiayou]
通讯作者:
Zhang,Jiayou
The potential role of photoelectron microscopy in the analysis of biological surfaces.
光电子显微镜在生物表面分析中的潜在作用。
DOI:
--
发表时间:
1984
期刊:
Scanning electron microscopy
影响因子:
--
作者:
[Griffith,OH, Nadakavukaren,KK, Jost,PC]
通讯作者:
Jost,PC
共 11 条
MUTATION AND RECOMBINATION OF RETROVIRUSES
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批准号:2397406
-
项目类别:
-
资助金额:$10.06万
-
财政年份:1997
-
负责人:JIAYOU ZHANG
-
依托单位:
MUTATION AND RECOMBINATION OF RETROVIRUSES
-
批准号:2748853
-
项目类别:
-
资助金额:$9.87万
-
财政年份:1997
-
负责人:JIAYOU ZHANG
-
依托单位:
MUTATION AND RECOMBINATION OF RETROVIRUSES
-
批准号:6173250
-
项目类别:
-
资助金额:$10.32万
-
财政年份:1997
-
负责人:JIAYOU ZHANG
-
依托单位:
MUTATION AND RECOMBINATION OF RETROVIRUSES
-
批准号:2895526
-
项目类别:
-
资助金额:$10.08万
-
财政年份:1997
-
负责人:JIAYOU ZHANG
-
依托单位:
海外基金