Multicenter Network of Neonatal Intensive Care Units

新生儿重症监护室多中心网络

• 批准号: 6331412
• 负责人: JON E. TYSON
• 金额: $ 15.56万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6331412
• 关键词: clinical trials; cooperative study; disease /disorder proneness /risk; health care facility information system; human subject; human therapy evaluation; low birth weight infant human; mother /infant health care; neonatal intensive care; newborn human (0-6 weeks); obstetrics; patient oriented research; pediatric nursing; pediatrics; perinatal; pregnancy disorder; premature infant human; prenatal care; prenatal diagnosis

The PI is Jon Tyson, MD, MPH, is the Michelle Bain Distinguished Professor of Medicine and Public Health, Director of the Center for Population Health and Evidence-Based Medicine, and a Professor of Pediatrics, Obstetrics, and Epidemiology at UT Houston. Th Co-PI is Kathleen Kennedy, MD who is an Associate Professor of Pediatrics and the Director of the Perinatal Epidemiology Program UT Houston was added to the Network in 1998 when the PI and Co-PI moved from UT Southwestern. UT Houston provides: A. A large and growing patient population. A total of 9,000 total births and 350 VLBW infants are projected this year for our 2 teaching hospitals: Memorial Hermann Hospital (a private hospital with an expanding referral base including 9 hospitals in the Memorial Hermann system [3 staffed by our Ob. Faculty]) and Lyndon Baines Johnson Hospital (a large county hospital with an increasing population). UT Houston's enrollment in the Glutamine Trial exceeds that for all but 2 of the other 13 Network centers. B. Strong, and highly supportive leadership at UT Houston. The Dean (Max Buja, MD) recruited Dr. Tyson to promote clinical research. The Ob. Chairman (Larry Gilstrap) is a perinatal investigator and Network consultant. The Pediatrics Chairman (John Sparks, MD) is a neonatologist and Network advocate. The Neonatology Director (Fernando Moya, MD) is Hermann Physician of the Year and skilled in conducting clinical research, eliciting hospital support, and augmenting enthusiasm for Network studies. C. An experienced and highly committed PI and Co-PI. Dr Tyson has been a PI for 13 years; Dr. Kennedy, Co-PI for 9 years and acting PI for 1 year. In the past 4 years, they have been an author on 16 Network publications, 3 as 1st author; 3 as 2nd author, and 1 as 3rd author. (4 of these were published in New England Journal or JAMA.) In moving to Houston, Dr. Tyson petitioned NICHD to include both UT Southwestern and UT Houston (rather than UT Houston only) in the Network and has served as PI for both. He has helped the Co-PI at UT Southwestern to apply as PI there for the next funding cycle. Dr. Tyson has involved multiple other faculty and fellows in the Network including Robert Lasky, PhD a developmental psychologist with expertise in neural processing; Terri Major-Kincade, MD,MPH, 1st recipient of the Network Specialized Clinical Investigator Development Award; and Martin Blakely, MD a pediatric surgeon whose K23 proposal (Dr. Tyson as mentor) is focused on Network studies. D. Methodological and multidisciplinary expertise. The Network can further advance the methods of clinical research and enrich the evaluation of important neonatal issues. Dr. Tyson is an epidemiologist and neonatologist, the PI for the NIH-funded Clinical Research Curriculum, and Director of the Master's Degree Program in Clinical Research to start here. The Center for Population Health and Evidence- Based Medicine that he directs includes 9 faculty with expertise in clinical or population-based epidemiology, biostatistics, developmental psychology, health care economics, and/or bioethics; 3 of these faculty are now involved in Network studies. John C. Sinclair, MD, an eminent neonatologist, clinical epidemiologist, and Network advisor, will join the Center Jan. 2001.

首席研究员是Jon Tyson，医学博士，公共卫生硕士，米歇尔·贝恩医学和公共卫生杰出教授，人口健康和循证医学中心主任，德州大学休斯顿分校儿科，产科和流行病学教授。副主任是凯瑟琳·肯尼迪医学博士，她是儿科副教授和围产期流行病学项目主任，德克萨斯大学休斯顿分校于1998年加入该网络，当时副主任和副主任从德克萨斯大学西南分校迁来。休斯敦大学提供：A.庞大且不断增长的患者群体。我们的两家教学医院：纪念赫尔曼医院（一家转诊基数不断扩大的私立医院，包括纪念赫尔曼系统中的9家医院[其中3家由我们的妇产科医生组成]）和林登贝恩斯约翰逊医院（一家人口不断增加的大型县医院），预计今年将有9000名新生儿和350名极低体重婴儿出生。休斯顿大学参加谷氨酰胺试验的人数超过了其他13个网络中心中的2个。B.德州大学休斯顿分校强有力的、高度支持的领导层。院长（Max Buja，医学博士）聘请泰森博士来促进临床研究。Ob主席（Larry Gilstrap）是围产期调查员和网络顾问。儿科主席（约翰·斯帕克斯，医学博士）是一名新生儿学家和网络倡导者。新生儿科主任（Fernando Moya，医学博士）是赫尔曼年度医生，擅长进行临床研究，获得医院支持，并增强网络研究的热情。C.经验丰富且高度忠诚的PI和Co-PI。泰森博士已经做了13年的私家侦探；肯尼迪博士，担任副PI 9年，代理PI 1年。近4年来，共发表网络出版物16篇，第一作者3篇；3人是第二作者，1人是第三作者。（其中4篇发表在《新英格兰杂志》或《美国医学会杂志》上。）搬到休斯顿后，泰森博士请求NICHD将德州大学西南分校和德州大学休斯顿分校（而不仅仅是德州大学休斯顿分校）纳入该网络，并担任两者的PI。他帮助西南大学的联合项目负责人申请下一个资助周期的项目负责人。泰森博士参与了该网络的其他多位教职员工和研究员，包括罗伯特·拉斯基博士，一位在神经处理方面具有专长的发展心理学家；Terri Major-Kincade，医学博士，公共卫生硕士，网络专业临床研究者发展奖的第一位获得者；Martin Blakely，医学博士，一位儿科外科医生，他的K23提案（泰森博士作为导师）专注于网络研究。D.方法学和多学科专业知识。该网络可以进一步推进临床研究方法，丰富对新生儿重要问题的评价。泰森博士是一名流行病学家和新生儿学家，美国国立卫生研究院资助的临床研究课程的PI，也是临床研究硕士学位课程的主任。他领导的人口健康和循证医学中心包括9名教师，他们在临床或基于人群的流行病学、生物统计学、发展心理学、卫生保健经济学和/或生物伦理学方面具有专业知识；这些教师中有3人现在参与网络研究。John C. Sinclair，医学博士，杰出的新生儿学家、临床流行病学家和网络顾问，将于2001年1月加入该中心。