Multicenter Network of Neonatal Intensive Care Units

新生儿重症监护室多中心网络

• 批准号: 6891934
• 负责人: JON E. TYSON
• 金额: $ 73.49万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6891934
• 关键词: clinical research; clinical trials; cooperative study; disease /disorder proneness /risk; health care facility information system; human subject; human therapy evaluation; low birth weight infant human; mother /infant health care; neonatal intensive care; newborn human (0-6 weeks); obstetrics; patient oriented research; pediatric nursing; pediatrics; perinatal; pregnancy disorder; premature infant human; prenatal care; prenatal diagnosis

The PI is Jon Tyson, MD, MPH, is the Michelle Bain Distinguished Professor of Medicine and Public Health, Director of the Center for Population Health and Evidence-Based Medicine, and a Professor of Pediatrics, Obstetrics, and Epidemiology at UT Houston. Th Co-PI is Kathleen Kennedy, MD who is an Associate Professor of Pediatrics and the Director of the Perinatal Epidemiology Program UT Houston was added to the Network in 1998 when the PI and Co-PI moved from UT Southwestern. UT Houston provides: A. A large and growing patient population. A total of 9,000 total births and 350 VLBW infants are projected this year for our 2 teaching hospitals: Memorial Hermann Hospital (a private hospital with an expanding referral base including 9 hospitals in the Memorial Hermann system [3 staffed by our Ob. Faculty]) and Lyndon Baines Johnson Hospital (a large county hospital with an increasing population). UT Houston's enrollment in the Glutamine Trial exceeds that for all but 2 of the other 13 Network centers. B. Strong, and highly supportive leadership at UT Houston. The Dean (Max Buja, MD) recruited Dr. Tyson to promote clinical research. The Ob. Chairman (Larry Gilstrap) is a perinatal investigator and Network consultant. The Pediatrics Chairman (John Sparks, MD) is a neonatologist and Network advocate. The Neonatology Director (Fernando Moya, MD) is Hermann Physician of the Year and skilled in conducting clinical research, eliciting hospital support, and augmenting enthusiasm for Network studies. C. An experienced and highly committed PI and Co-PI. Dr Tyson has been a PI for 13 years; Dr. Kennedy, Co-PI for 9 years and acting PI for 1 year. In the past 4 years, they have been an author on 16 Network publications, 3 as 1st author; 3 as 2nd author, and 1 as 3rd author. (4 of these were published in New England Journal or JAMA.) In moving to Houston, Dr. Tyson petitioned NICHD to include both UT Southwestern and UT Houston (rather than UT Houston only) in the Network and has served as PI for both. He has helped the Co-PI at UT Southwestern to apply as PI there for the next funding cycle. Dr. Tyson has involved multiple other faculty and fellows in the Network including Robert Lasky, PhD a developmental psychologist with expertise in neural processing; Terri Major-Kincade, MD,MPH, 1st recipient of the Network Specialized Clinical Investigator Development Award; and Martin Blakely, MD a pediatric surgeon whose K23 proposal (Dr. Tyson as mentor) is focused on Network studies. D. Methodological and multidisciplinary expertise. The Network can further advance the methods of clinical research and enrich the evaluation of important neonatal issues. Dr. Tyson is an epidemiologist and neonatologist, the PI for the NIH-funded Clinical Research Curriculum, and Director of the Master's Degree Program in Clinical Research to start here. The Center for Population Health and Evidence- Based Medicine that he directs includes 9 faculty with expertise in clinical or population-based epidemiology, biostatistics, developmental psychology, health care economics, and/or bioethics; 3 of these faculty are now involved in Network studies. John C. Sinclair, MD, an eminent neonatologist, clinical epidemiologist, and Network advisor, will join the Center Jan. 2001.

PI是Jon Tyson，MD，MPH，是医学和公共卫生的Michelle Bain杰出教授，人口健康和循证医学中心主任，以及UT Houston的儿科，产科和流行病学教授。Th co-PI是Kathleen Kennedy，医学博士，他是儿科副教授，也是UT Houston围产期流行病学项目的主任，1998年PI和Co-PI从UT Southwestern转移到该网络。UT Houston提供：A.庞大且不断增长的患者群体。预计今年我们的2家教学医院将有9,000名新生儿和350名极低出生体重婴儿：纪念赫尔曼医院（一家私立医院，转诊基础不断扩大，包括纪念赫尔曼系统的9家医院[3]，由我们的产科医生组成。教师]）和林登贝恩斯约翰逊医院（一个大的县医院，人口不断增加）。UT休斯顿在谷氨酰胺试验中的注册人数超过了其他13个网络中心中的2个。B。强大的，并在UT休斯顿高度支持的领导。院长（马克斯布贾，医学博士）招募泰森博士促进临床研究。Ob。主席（拉里吉尔斯特普）是围产期调查和网络顾问。儿科主席（John Sparks，MD）是一位儿科医生和网络倡导者。新生儿科主任（Fernando莫亚，医学博士）是赫尔曼年度最佳医师，擅长开展临床研究，获得医院支持，并提高对网络研究的热情。C.一位经验丰富、高度敬业的PI和Co-PI。Tyson博士担任PI已有13年; Kennedy博士担任Co-PI已有9年，代理PI已有1年。在过去的4年里，他们是16个网络出版物的作者，3个是第一作者，3个是第二作者，1个是第三作者。（其中4篇发表在《新英格兰杂志》或《美国医学会杂志》上。）泰森请愿NICHD包括UT西南和UT休斯顿（而不是UT休斯顿只）在网络中，并担任PI两者。他帮助德州西南大学的共同PI申请成为下一个融资周期的PI。Tyson博士还参与了网络中的多个其他教师和研究员，包括Robert Lasky博士，他是一位在神经处理方面具有专业知识的发展心理学家; Terri Major-Kincade，医学博士，公共卫生硕士，网络专业临床研究者发展奖的第一位获得者;和Martin Blakely，医学博士，一位儿科外科医生，他的K23提案（Tyson博士作为导师）专注于网络研究。D.方法和多学科专门知识。该网络可以进一步推进临床研究方法，丰富对重要新生儿问题的评价。Tyson博士是一位流行病学家和病理学家，NIH资助的临床研究课程的PI，以及临床研究硕士学位课程的主任。他指导的人口健康和循证医学中心包括9名具有临床或基于人口的流行病学，生物统计学，发展心理学，卫生保健经济学和/或生物伦理学专业知识的教师;其中3名教师现在参与网络研究。John C. Sinclair，MD，一位杰出的临床流行病学家，临床流行病学家和网络顾问，将于2001年1月加入该中心。