Multicenter Network of Neonatal Intensive Care Units

新生儿重症监护室多中心网络

• 批准号: 6645449
• 负责人: JON E. TYSON
• 金额: $ 43.27万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6645449
• 关键词: clinical trials; cooperative study; disease /disorder proneness /risk; health care facility information system; human subject; human therapy evaluation; low birth weight infant human; mother /infant health care; neonatal intensive care; newborn human (0-6 weeks); obstetrics; patient oriented research; pediatric nursing; pediatrics; perinatal; pregnancy disorder; premature infant human; prenatal care; prenatal diagnosis

The PI is Jon Tyson, MD, MPH, is the Michelle Bain Distinguished Professor of Medicine and Public Health, Director of the Center for Population Health and Evidence-Based Medicine, and a Professor of Pediatrics, Obstetrics, and Epidemiology at UT Houston. Th Co-PI is Kathleen Kennedy, MD who is an Associate Professor of Pediatrics and the Director of the Perinatal Epidemiology Program UT Houston was added to the Network in 1998 when the PI and Co-PI moved from UT Southwestern. UT Houston provides: A. A large and growing patient population. A total of 9,000 total births and 350 VLBW infants are projected this year for our 2 teaching hospitals: Memorial Hermann Hospital (a private hospital with an expanding referral base including 9 hospitals in the Memorial Hermann system [3 staffed by our Ob. Faculty]) and Lyndon Baines Johnson Hospital (a large county hospital with an increasing population). UT Houston's enrollment in the Glutamine Trial exceeds that for all but 2 of the other 13 Network centers. B. Strong, and highly supportive leadership at UT Houston. The Dean (Max Buja, MD) recruited Dr. Tyson to promote clinical research. The Ob. Chairman (Larry Gilstrap) is a perinatal investigator and Network consultant. The Pediatrics Chairman (John Sparks, MD) is a neonatologist and Network advocate. The Neonatology Director (Fernando Moya, MD) is Hermann Physician of the Year and skilled in conducting clinical research, eliciting hospital support, and augmenting enthusiasm for Network studies. C. An experienced and highly committed PI and Co-PI. Dr Tyson has been a PI for 13 years; Dr. Kennedy, Co-PI for 9 years and acting PI for 1 year. In the past 4 years, they have been an author on 16 Network publications, 3 as 1st author; 3 as 2nd author, and 1 as 3rd author. (4 of these were published in New England Journal or JAMA.) In moving to Houston, Dr. Tyson petitioned NICHD to include both UT Southwestern and UT Houston (rather than UT Houston only) in the Network and has served as PI for both. He has helped the Co-PI at UT Southwestern to apply as PI there for the next funding cycle. Dr. Tyson has involved multiple other faculty and fellows in the Network including Robert Lasky, PhD a developmental psychologist with expertise in neural processing; Terri Major-Kincade, MD,MPH, 1st recipient of the Network Specialized Clinical Investigator Development Award; and Martin Blakely, MD a pediatric surgeon whose K23 proposal (Dr. Tyson as mentor) is focused on Network studies. D. Methodological and multidisciplinary expertise. The Network can further advance the methods of clinical research and enrich the evaluation of important neonatal issues. Dr. Tyson is an epidemiologist and neonatologist, the PI for the NIH-funded Clinical Research Curriculum, and Director of the Master's Degree Program in Clinical Research to start here. The Center for Population Health and Evidence- Based Medicine that he directs includes 9 faculty with expertise in clinical or population-based epidemiology, biostatistics, developmental psychology, health care economics, and/or bioethics; 3 of these faculty are now involved in Network studies. John C. Sinclair, MD, an eminent neonatologist, clinical epidemiologist, and Network advisor, will join the Center Jan. 2001.

PIS是乔恩·泰森，医学博士，公共卫生硕士，米歇尔·贝恩医学和公共卫生特聘教授，人口健康和循证医学中心主任，德克萨斯大学休斯顿分校儿科学、产科和流行病学教授。共同派是凯瑟琳·肯尼迪，医学博士，儿科学副教授和围产期流行病学项目主任，德克萨斯大学休斯顿是在1998年当派和联合派从德克萨斯大学西南搬到网络时加入的。德克萨斯大学休斯顿分校提供：a.庞大且不断增长的患者群体。今年，我们的两家教学医院预计总共将有9,000名新生儿和350名极低出生体重儿：赫尔曼纪念医院(一家私立医院，转诊基础不断扩大，包括纪念赫尔曼系统中的9家医院[3名由我们的产科人员组成。学院])和林登·贝恩斯·约翰逊医院(一家人口不断增加的大型县医院)。德克萨斯大学休斯顿分校谷氨酰胺试验的登记人数超过了其他13个网络中心中除2个以外的所有中心。B.德克萨斯大学休斯顿分校强大、高度支持的领导层。院长(Max Buja，医学博士)聘请了泰森博士来促进临床研究。妇产科医生。主席(拉里·吉尔斯特拉普)是一名围产期调查员和网络顾问。儿科主席(约翰·斯帕克斯，医学博士)是一位新生儿专家和网络倡导者。新生儿科主任(费尔南多·莫亚，医学博士)是赫尔曼年度最佳医生，擅长进行临床研究，吸引医院支持，并增强对网络研究的热情。C.一位经验丰富、高度忠诚的PI和共同PI。泰森博士担任私人助理已有13年，肯尼迪博士担任联合私人助理已有9年，代理私人助理已有1年。在过去的4年里，他们在16种网络出版物上担任作者，其中3人为第一作者，3人为第二作者，1人为第三作者。(其中4篇发表在《新英格兰杂志》或《美国医学会杂志》上。)在搬到休斯顿后，泰森博士请求NICHD将德克萨斯大学西南分校和德克萨斯大学休斯顿分校(而不仅仅是休斯顿分校)都纳入该网络，并担任这两个项目的PI。他帮助德克萨斯大学西南分校的合作私募申请下一个资金周期的私募股权投资。泰森博士还参与了该网络的其他多名教职员工和研究员的工作，其中包括具有神经处理专业知识的发展心理学家罗伯特·拉斯基博士、医学博士特里·梅杰-金卡德、公共卫生硕士特里·梅杰·金卡德、网络专门临床研究者发展奖第一名获得者特里·梅杰·金卡德以及儿科外科医生马丁·布莱克利，他的K23计划(泰森博士担任导师)侧重于网络研究。D.方法和多学科的专门知识。该网络可以进一步推进临床研究的方法，丰富对重要新生儿问题的评估。泰森博士是一名流行病学家和新生儿专家，是美国国立卫生研究院资助的临床研究课程的PI，也是从这里开始的临床研究硕士学位项目的主任。他领导的人口健康和循证医学中心包括9名在临床或基于人口的流行病学、生物统计学、发展心理学、保健经济学和/或生物伦理学方面具有专业知识的教员；其中3名教员目前参与了网络研究。约翰·C·辛克莱医学博士是一位杰出的新生儿学家、临床流行病学家和网络顾问，他将于2001年1月加入该中心。