NATIONAL DRUG ABUSE TREATMENT CLINICAL TRIALS NETWORK

产品说明：（申请人摘要）这是第一次重新提交的建议，建立一个东南杜克节点在NIDA国家药物滥用临床试验网络。我们将与至少10个真实的世界社区治疗项目（CTP）合作。现金转拨方案反映了不同的人口情况;有几个方案是在农村或小城镇。CTP不仅将实施现有的研究协议，还将与Node科学家合作开发新的研究概念。CTP的协调以及与其他节点和NIDA的接口将由区域研究和培训中心（RRTC）指导，该中心代表来自杜克大学医学中心（DUMC）精神病学系、杜克临床研究所（DCRI）、和国家发展研究院（NDRI），每个都有自己的优势和相互合作的历史。RRTC将维护临床基础设施和研究基础设施，并负责开展临床试验的所有方面。概念研究的建议，可以利用独特的范围CTN划定：1）多模式CBT的青少年药物滥用者内化障碍和2）司来吉兰/CBT可卡因依赖。为了加强我们对CTN专注于多中心，有效性研究设计的贡献，我们指定Robert Hubbard博士为PI，并增加了DUMC-DCRI有效性研究专家的骨干，他们将扩大我们研究的包容性，普遍性和实用性。

DESCRIPTION: (Applicant's Abstract) This is the first resubmission of a proposal to establish a Southeastern Duke Node in the NIDA National Drug Abuse Clinical Trials Network. We will partner with at least 10 real world community-based treatment programs (CTPs). The CTPs reflect diverse demographics; several are in rural or small town settings. CTPs will not only implement existing research protocols but will collaborate with Node scientists to develop new research concepts. The coordination of the CTPs and the interface with other Nodes and NIDA will be directed by a Regional Research and Training Center (RRTC) that represents a confederation of investigators, trainers and research monitors from Duke University Medical Center (DUMC) Department of Psychiatry, the Duke Clinical Research Institute (DCRI), and the National Development and Research Institutes (NDRI) each with their own strengths and a history of collaborating with each other. The RRTC will maintain the clinical infrastructure and the research infrastructure and will be responsible for all aspects of conducting clinical trials. Concept research proposals that can utilize the unique scope of the CTN are delineated: 1) Multi-modal CBT for adolescent substance abusers with internalizing disorders and 2) Selegiline/CBT for cocaine dependence. To enhance our contribution to the CTN's focus on multi-center, effectiveness research designs, we have designated Dr. Robert Hubbard as PI and added a cadre of DUMC-DCRI experts on effectiveness research who will broaden the inclusiveness, generalizability and usefulness of our studies.