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Synthetic Biology: Development and Application Cellular Computation Devices

合成生物学：细胞计算设备的开发与应用

基本信息

批准号：
1618786
负责人：
金额：
--
依托单位：
University of Manchester
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1618786
关键词：
Synthetic Biology Development Application Cellular

项目摘要

Synthetic biology seeks to design and integrate novel devices, parts and tools for the predictive engineering of biological systems, and the field offers great hope for the rationalization of strain development for biotechnological and biomedical applications. Synthetic gene circuits can also be used to perform various logic functions to permit cellular computation, including toggle switches, Boolean logic gates, edge detection, analogue to digital signal conversion, memory, and simple addition and subtraction.The aim of this research project is to use these guiding principles to develop tools and devices (biosensors and cellular computers) for the optimization of biotechnological production process for a range of applications including biofuels, (bio)chemicals, enzymes, and biopharmaceuticals.This research project will engineer cells with computational capacity to sense and respond to metabolic and environmental signals and to develop tools for both system monitoring and intervention. This capacity has a number of applications for low-level signal detection, precise threshold detection, and enhanced digital to analogue signal conversion, for the optimization of biotechnological processes. This project will be supported by in-house expertise and technologies including use of riboswitches, SpeedyGenes, and aptamer array technology. The PhD student will be trained in broad aspects of synthetic biology, analytical biotechnology and computational modelling; skills that are highly relevant for future careers in academia and/or biotechnology related industries. They will additionally have the opportunity to interact with industrial collaborations, attend meetings/conferences, and to broaden their academic and industry networks/contacts.

合成生物学旨在为生物系统的预测工程设计和集成新的设备，部件和工具，该领域为生物技术和生物医学应用的菌株开发合理化提供了巨大的希望。合成基因电路也可用于执行各种逻辑功能，以允许细胞计算，包括拨动开关，布尔逻辑门，边缘检测，模拟到数字信号转换，存储器，和简单的加法和减法。该研究项目的目的是利用这些指导原则来开发工具和设备（生物传感器和细胞计算机），以优化生物技术生产过程，用于包括生物燃料、（生物）化学品、酶和生物制药在内的一系列应用。该研究项目将设计具有计算能力的细胞，以感知和响应代谢和环境信号，并开发用于系统监测和干预的工具。这种能力在低水平信号检测、精确阈值检测和增强的数字到模拟信号转换方面有许多应用，用于优化生物技术过程。该项目将由内部专业知识和技术支持，包括使用核糖开关、SpeedyGenes和适体阵列技术。博士生将在合成生物学、分析生物技术和计算建模的广泛方面接受培训；与未来在学术界和/或生物技术相关行业的职业高度相关的技能。此外，他们还将有机会与工业合作进行互动，参加会议/会议，并扩大他们的学术和行业网络/联系。