Compulsive Drug-Related Behavior/Classical Condition

强迫性药物相关行为/典型状况

• 批准号: 6445392
• 负责人: DAVID N KEARNS
• 金额: $ 2.21万
• 依托单位: AMERICAN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-10-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6445392
• 关键词: behavior test; behavioral /social science research tag; cocaine; compulsive behavior; conditioning; craving; cues; disease /disorder etiology; disease /disorder model; drug abuse; drug addiction; drug habituation; laboratory rat; paired stimuli; predoctoral investigator; reinforcer; self medication; substance abuse related behavior

The goal of the proposed research is to identify variables related to classical conditioning that may contribute to the rapid escalation and compulsivity of drug-taking and drug-seeking behavior observed in human drug abusers. The first of the proposed experiments will examine the ability of drug-associated stimuli to attract the organism and elicit approach and contact behavior. This experiment will explore the variables relevant to producing auto shaping (Brown & Jenkins, 1968) with cocaine as the reinforcer. A second experiment will determine the extent to which behavior elicited by drug-associated stimuli is compulsive and insensitive to instrumental contingencies. An omission training procedure (e.g., Williams & Williams, 1969) will be used where approaching and contacting the drug-paired stimulus results in a loss of reinforcement. A third experiment will examine the ability of behavior elicited by drug-associated stimuli to enhance rates of drug-seeking and drug-taking behavior. This will be accomplished by using a behavioral contrast procedure (Reynolds, 196 1), where responding will be maintained by cocaine self-administration.

拟议研究的目标是确定与经典相关的变量 条件反射，可能有助于快速升级和强迫性的 在人类药物滥用者中观察到的药物服用和药物寻求行为。第一 的拟议实验将检查药物相关的刺激的能力， 来吸引生物体并引发接近和接触行为。这 实验将探索与产生自动成形相关的变量（布朗 & Jenkins，1968），可卡因作为麻醉剂。第二个实验将 确定药物相关刺激引起的行为在多大程度上 强迫性的，对工具性的偶然事件不敏感的。一次省略训练 程序（例如，威廉姆斯和威廉姆斯，1969年）将用于接近和 接触药物配对刺激导致强化的丧失。第三 实验将检查药物相关的行为引起的能力， 刺激，以提高吸毒和吸毒行为的速度。这将是 通过使用行为对比程序（Reynolds，196 1）完成，其中 将通过可卡因自我给药来维持应答。