Compulsive Drug-Related Behavior & Classical Condition

强迫性药物相关行为

• 批准号: 6542896
• 负责人: DAVID N KEARNS
• 金额: $ 0.05万
• 依托单位: AMERICAN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-13 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6542896
• 关键词: behavior test; behavioral /social science research tag; cocaine; compulsive behavior; conditioning; craving; cues; disease /disorder etiology; disease /disorder model; drug abuse; drug addiction; drug habituation; laboratory rat; paired stimuli; predoctoral investigator; reinforcer; self medication; substance abuse related behavior

The goal of the proposed research is to identify variables related to classical conditioning that may contribute to the rapid escalation and compulsivity of drug-taking and drug-seeking behavior observed in human drug abusers. The first of the proposed experiments will examine the ability of drug-associated stimuli to attract the organism and elicit approach and contact behavior. This experiment will explore the variables relevant to producing auto shaping (Brown & Jenkins, 1968) with cocaine as the reinforcer. A second experiment will determine the extent to which behavior elicited by drug-associated stimuli is compulsive and insensitive to instrumental contingencies. An omission training procedure (e.g., Williams & Williams, 1969) will be used where approaching and contacting the drug-paired stimulus results in a loss of reinforcement. A third experiment will examine the ability of behavior elicited by drug-associated stimuli to enhance rates of drug-seeking and drug-taking behavior. This will be accomplished by using a behavioral contrast procedure (Reynolds, 196 1), where responding will be maintained by cocaine self-administration.

拟议研究的目标是找出与经典 可能导致快速升级和强制性的条件反射 在人类吸毒者中观察到的吸毒和寻求毒品行为。第一 将检验药物相关刺激的能力 吸引生物体，引出接近和接触行为。这 实验将探索与自动成形(Brown)相关的变量 &Jenkins，1968)，以可卡因为增强剂。第二个实验将 确定药物相关刺激引起的行为在多大程度上 强迫性的，对工具性突发事件不敏感的。一次遗漏训练 程序(例如，Williams&Williams，1969)将在接近和 接触与药物配对的刺激会导致增强作用的丧失。三分之一 实验将检验药物相关行为的能力 刺激，以提高寻求毒品和吸毒行为的比率。这将是 通过使用行为对比程序来完成(雷诺兹，196 1)，其中 应对措施将由可卡因自我管理来维持。