Compulsive Drug-Related Behavior/Classical Condition

拟议研究的目标是确定与经典相关的变量 条件反射，可能有助于快速升级和强迫性的 在人类药物滥用者中观察到的药物服用和药物寻求行为。第一 的拟议实验将检查药物相关的刺激的能力， 来吸引生物体并引发接近和接触行为。这 实验将探索与产生自动成形相关的变量（布朗 & Jenkins，1968），可卡因作为麻醉剂。第二个实验将 确定药物相关刺激引起的行为在多大程度上 强迫性的，对工具性的偶然事件不敏感的。一次省略训练 程序（例如，威廉姆斯和威廉姆斯，1969年）将用于接近和 接触药物配对刺激导致强化的丧失。第三 实验将检查药物相关的行为引起的能力， 刺激，以提高吸毒和吸毒行为的速度。这将是 通过使用行为对比程序（Reynolds，196 1）完成，其中 将通过可卡因自我给药来维持应答。

The goal of the proposed research is to identify variables related to classical conditioning that may contribute to the rapid escalation and compulsivity of drug-taking and drug-seeking behavior observed in human drug abusers. The first of the proposed experiments will examine the ability of drug-associated stimuli to attract the organism and elicit approach and contact behavior. This experiment will explore the variables relevant to producing auto shaping (Brown & Jenkins, 1968) with cocaine as the reinforcer. A second experiment will determine the extent to which behavior elicited by drug-associated stimuli is compulsive and insensitive to instrumental contingencies. An omission training procedure (e.g., Williams & Williams, 1969) will be used where approaching and contacting the drug-paired stimulus results in a loss of reinforcement. A third experiment will examine the ability of behavior elicited by drug-associated stimuli to enhance rates of drug-seeking and drug-taking behavior. This will be accomplished by using a behavioral contrast procedure (Reynolds, 196 1), where responding will be maintained by cocaine self-administration.