Incentive Properties of Abused Drugs
滥用药物的激励特性
基本信息
- 批准号:8505428
- 负责人:
- 金额:$ 25.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1996
- 资助国家:美国
- 起止时间:1996-09-01 至 2016-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAgreementAnimal ModelBehaviorBehavioralClinicalCocaineCuesDevelopmentDrug CombinationsDrug ControlsDrug abuseDrug userEffectivenessExtinction (Psychology)FundingGoalsGrantHealthHeroinIncentivesIndividualIntakeInterventionLeadLearningMethodsModelingNational Institute of Drug AbuseOutcomePharmaceutical PreparationsPharmacologic SubstanceProceduresProcessPropertyPsychological reinforcementPublic HealthRecording of previous eventsRelapseResearchSignal TransductionStimulusTechniquesbasedrug abuserdrug cravingdrug of abuseeffective therapyexpectationinhibitor/antagonistinsightlearning extinctionnon-drugprograms
项目摘要
DESCRIPTION (provided by applicant): Drug-related stimuli can elicit drug craving in drug abusers and have been implicated in relapse. An important objective of drug abuse treatment is to reduce or eliminate the control that these cues have over individuals. The goal of the research proposed here is to use an animal model to develop procedures that can be used to effectively treat drug cues. Specifically, we will investigate techniques for temporarily restoring or amplifying the expectation-outcome error signal produced by non-reinforcement as a means of enhancing extinction and conditioned inhibition of drug seeking. The first aim of the proposed research is to develop a way to deepen the extinction of drug cues by using combinations of drug- as well as non-drug- related stimuli to increase the error signal generated during extinction learning. A second aim is to create similar procedures that deepen the conditioned inhibition of drug seeking. A third aim is to deepen the extinction of drug cues by pharmacologically-reinstating the effects of a previously extinguished drug cue prior to exposing that cue to additional, extensive extinction. Achieving these aims could (1) provide insight into ways of enhancing the extinction and conditioned inhibition of drug seeking via behavioral and pharmacological interventions, and (2) form the empirical basis for the creation of an effective extinction- based treatment for drug abuse, a major public health problem.
描述(由申请人提供):药物相关刺激可引起药物滥用者的药物渴求,并与复吸有关。药物滥用治疗的一个重要目标是减少或消除这些线索对个体的控制。这里提出的研究目标是使用动物模型来开发可用于有效治疗药物线索的程序。具体来说,我们将研究技术暂时恢复或放大的预期结果错误信号产生的非强化作为一种手段,提高灭绝和条件抑制药物寻求。该研究的第一个目的是开发一种方法,通过使用药物和非药物相关刺激的组合来加深药物线索的消退,以增加消退学习过程中产生的错误信号。第二个目标是创造类似的程序,加深对药物寻求的条件抑制。第三个目标是通过药理学恢复先前熄灭的药物线索的效果,然后将该线索暴露于额外的广泛的灭绝,来加深药物线索的灭绝。实现这些目标可以(1)通过行为和药理学干预,为增强药物寻求的消退和条件抑制提供洞察力,(2)为药物滥用(一个主要的公共卫生问题)创建有效的基于消退的治疗方法奠定经验基础。
项目成果
期刊论文数量(27)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Cocaine cues retain silent traces of an excitatory history after conversion into conditioned inhibitors: 'the ghost in the addict'.
- DOI:10.1097/fbp.0000000000000220
- 发表时间:2016-04
- 期刊:
- 影响因子:1.6
- 作者:Weiss SJ;Kearns DN
- 通讯作者:Kearns DN
Sign-tracking (autoshaping) in rats: a comparison of cocaine and food as unconditioned stimuli.
大鼠的体征追踪(自动塑造):可卡因和食物作为无条件刺激的比较。
- DOI:10.3758/bf03196042
- 发表时间:2004
- 期刊:
- 影响因子:1.8
- 作者:Kearns,DavidN;Weiss,StanleyJ
- 通讯作者:Weiss,StanleyJ
Extinction of goal tracking also eliminates the conditioned reinforcing effects of an appetitive conditioned stimulus.
目标追踪的消失也消除了食欲性条件刺激的条件强化效应。
- DOI:10.3758/s13423-011-0187-5
- 发表时间:2012
- 期刊:
- 影响因子:3.5
- 作者:Kearns,DavidN;Tunstall,BrendanJ;Marks,KatherineR;Weiss,StanleyJ
- 通讯作者:Weiss,StanleyJ
Outcome specificity in deepened extinction may limit treatment feasibility: co-presentation of a food cue interferes with extinction of cue-elicited cocaine seeking.
加深消退的结果特异性可能会限制治疗的可行性:食物提示的共同呈现会干扰提示引起的可卡因寻求的消退。
- DOI:10.1016/j.drugalcdep.2013.08.029
- 发表时间:2013
- 期刊:
- 影响因子:4.2
- 作者:Tunstall,BrendanJ;Verendeev,Andrey;Kearns,DavidN
- 通讯作者:Kearns,DavidN
Lifetime needle sharing: a predictive analysis.
终身针共享:预测分析。
- DOI:10.1016/0740-5472(94)90098-1
- 发表时间:1994
- 期刊:
- 影响因子:3.9
- 作者:Kleinman,PH;Millman,RB;Robinson,H;Lesser,M;Hsu,C;Engelhart,P;Finkelstein,I
- 通讯作者:Finkelstein,I
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DAVID N KEARNS其他文献
DAVID N KEARNS的其他文献
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{{ truncateString('DAVID N KEARNS', 18)}}的其他基金
Opioid and Psychostimulant Taking: Testing the Impact of Behavioral Economic Contexts
阿片类药物和精神兴奋剂服用:测试行为经济背景的影响
- 批准号:
10415491 - 财政年份:2022
- 资助金额:
$ 25.63万 - 项目类别:
Opioid and Psychostimulant Taking: Testing the Impact of Behavioral Economic Contexts
阿片类药物和精神兴奋剂服用:测试行为经济背景的影响
- 批准号:
10703398 - 财政年份:2022
- 资助金额:
$ 25.63万 - 项目类别:
Addiction as Maladaptive Choice of Drugs over Non-Drug Rewards
成瘾是药物相对于非药物奖励的适应不良选择
- 批准号:
8996682 - 财政年份:2015
- 资助金额:
$ 25.63万 - 项目类别:
Compulsive Drug-Related Behavior & Classical Condition
强迫性药物相关行为
- 批准号:
6542896 - 财政年份:2002
- 资助金额:
$ 25.63万 - 项目类别:
Compulsive Drug-Related Behavior/Classical Condition
强迫性药物相关行为/典型状况
- 批准号:
6663078 - 财政年份:2002
- 资助金额:
$ 25.63万 - 项目类别:
Compulsive Drug-Related Behavior/Classical Condition
强迫性药物相关行为/典型状况
- 批准号:
6445392 - 财政年份:2001
- 资助金额:
$ 25.63万 - 项目类别:
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